Michael J. Quon
University of Maryland, Baltimore
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
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Publications 238
#1Jeannie Tay (UAB: University of Alabama at Birmingham)H-Index: 7
#2Amy M. Goss (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Barbara A. Gower (UAB: University of Alabama at Birmingham)H-Index: 53
view all 8 authors...
BACKGROUND: Race differences in body composition and fat distribution may in part explain the differences in insulin sensitivity and the disproportionate burden of type 2 diabetes in African Americans. OBJECTIVE: To determine if differences in body composition and fat distribution explain race differences in insulin sensitivity and identify obesity measures that were independently associated with insulin sensitivity. METHODS: Participants were 113 lean, overweight, and obese African-American and...
#2Sunder MudaliarH-Index: 54
Last. Michael J. QuonH-Index: 75
view all 7 authors...
#1Xiaoquan Rao (Case Western Reserve University)H-Index: 6
#2Jeffrey A. Deiuliis (Case Western Reserve University)H-Index: 19
Last. Jixin Zhong (Case Western Reserve University)H-Index: 22
view all 12 authors...
Studies including ours indicate that systemic inhibition of dipeptidyl peptidase 4 (DPP4), an ubiquitously expressed peptidase, by pharmaceutical inhibitors improved atherosclerosis (1,2). However, the role of immune cell–derived DPP4 is not well defined in atherosclerosis. Our previous work demonstrated that DPP4 expression on monocytes/macrophages was increased in obesity and associated with the degree of insulin resistance (3). To test if the obesity-related increase of monocyte DPP4 plays a ...
1 CitationsSource
#1Kikumi D. Ono-Moore (USDA: United States Department of Agriculture)H-Index: 4
#2Ling Zhao (UT: University of Tennessee)
Last. Daniel H. Hwang (USDA: United States Department of Agriculture)H-Index: 48
view all 11 authors...
Introduction Chronic low-grade inflammation is associated with obesity and diabetes. However, what causes and mediates chronic inflammation in metabolic disorders is not well understood. Toll-like receptor 4 (TLR4) mediates both infection-induced and sterile inflammation by recognizing pathogen-associated molecular patterns and endogenous molecules, respectively. Saturated fatty acids can activate TLR4, and TLR4-deficient mice were protected from high fat diet (HFD)-induced obesity and insulin r...
#1Xiao Jian SunH-Index: 38
#2Soohyun P. KimH-Index: 4
Last. Michael J. QuonH-Index: 75
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Abstract Chronic inflammation may contribute to insulin resistance (IR) via molecular cross-talk between pathways for pro-inflammatory and insulin signaling. Interleukin 1 receptor associated kinase 1 (IRAK1) mediates pro-inflammatory signaling via IL-1 receptor/Toll-like receptors, which may contribute to insulin resistance, but this hypothesis is untested. Here, we used male Irak1 null (k/o) mice to investigate the metabolic role of IRAK1. C57BL/6 wild-type (WT) and k/o mice had comparable bod...
7 CitationsSource
#1Kwangkonkoh (Gachon University)H-Index: 44
#2Ichiro Sakuma (HSUH: Health Sciences University of Hokkaido)H-Index: 3
Last. Michael J. Quon (UMB: University of Maryland, Baltimore)H-Index: 75
view all 5 authors...
6 CitationsSource
#1Huei L.H. Ng (UTAS: University of Tasmania)H-Index: 3
#2Dino Premilovac (UTAS: University of Tasmania)H-Index: 7
Last. Michelle A. Keske (UTAS: University of Tasmania)H-Index: 12
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Epidemiological studies show a dose-dependent relationship between green tea consumption and reduced risk for type 2 diabetes and cardiovascular disease. Bioactive compounds in green tea including the polyphenol epigallocatechin 3-gallate (EGCG) have insulin-mimetic actions on glucose metabolism and vascular function in isolated cell culture studies. The aim of this study is to explore acute vascular and metabolic actions of EGCG in skeletal muscle of Sprague-Dawley rats. Direct vascular and met...
3 CitationsSource
#1Carmela Nacci (University of Bari)H-Index: 11
#2Valentina Leo (University of Bari)H-Index: 4
Last. Monica Montagnani (University of Bari)H-Index: 28
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Abstract Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM by reducing adiponectin (Ad) synthesis and therefore impairing Ad-mediated activity in the contiguous blood vessel system. We evaluated whether in vivo treatment with the TNFα blocking antibody infliximab normalized expression of Ad and Ad receptors in various fat depots, and whether this effect correlated with improved endothelial activity...
5 CitationsSource
#1Feng FuH-Index: 31
#2Kun ZhaoH-Index: 1
Last. Feng GaoH-Index: 92
view all 17 authors...
Direct Evidence that Myocardial Insulin Resistance following Myocardial Ischemia Contributes to Post-Ischemic Heart Failure
7 CitationsSource
#1Adina Maniu (UMB: University of Maryland, Baltimore)H-Index: 2
#2Graham W. Aberdeen (UMB: University of Maryland, Baltimore)H-Index: 16
Last. Eugene D. Albrecht (UMB: University of Maryland, Baltimore)H-Index: 34
view all 8 authors...
This study tested the hypothesis that estrogen programs mechanisms within the primate fetus that promote insulin sensitivity and glucose homeostasis in offspring. Glucose tolerance tests were performed longitudinally in prepubertal offspring of baboons untreated or treated on days 100 to 165/175 of gestation (term is 184 days) with the aromatase inhibitor letrozole, which decreased fetal estradiol levels by 95%. Basal plasma insulin levels were over two-fold greater in offspring delivered to let...
5 CitationsSource