Joline W.J. Beulens
Public Health Research Institute
Publications 245
#1Robert W. Koivula (University of Oxford)H-Index: 8
#2Naeimeh Atabaki-Pasdar (Lund University)H-Index: 3
Last.Søren Brunak (DTU: Technical University of Denmark)H-Index: 91
view all 34 authors...
It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a mechanistic basis for impairment in glycaemic control through the interactions of substrate availability, substrate metabolism and abdominal ectopic fat accumulation. Here, we hypothesise that the effect of physical activity in glucose regulation is mediated by the tw...
#1Nynke Simons (UM: Maastricht University)H-Index: 2
#2Mitchell Bijnen (UM: Maastricht University)
Last.Nicolaas C. Schaper (UM: Maastricht University)H-Index: 44
view all 13 authors...
#1Annemarie M. den Harder (UU: Utrecht University)H-Index: 10
#2Jelmer M. Wolterink (UU: Utrecht University)H-Index: 14
Last.Pim A. de Jong (UU: Utrecht University)H-Index: 37
view all 10 authors...
Background Microcalcifications cannot be identified with the present resolution of CT; however, 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) imaging has been proposed for non-invasive identification of microcalcification. The primary objective of this study was to assess whether 18F-NaF activity can assess the presence and predict the progression of CT detectable vascular calcification.
#1Laura H van Dongen (UvA: University of Amsterdam)
#2Marieke T. Blom (UvA: University of Amsterdam)H-Index: 18
Last.Hanno L. Tan (UvA: University of Amsterdam)H-Index: 52
view all 8 authors...
Abstract Background and aims Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM). Methods and results We included 778 participants from the Hoorn Study (aged 68.4 ± 7.2 years, 49% women), a population-based prospective cohort ...
#1Jun Liu (University of Oxford)H-Index: 9
#2Lies Lahousse (UGent: Ghent University)H-Index: 19
Last.Cornelia M. van Duijn (University of Oxford)H-Index: 14
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Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 dr...
#1Roderick C. Slieker (VUMC: Vanderbilt University Medical Center)
#2Amber A. W. H. van der Heijden (VUMC: Vanderbilt University Medical Center)
Last.Joline W.J. Beulens (UU: Utrecht University)H-Index: 50
view all 6 authors...
Background Glycemic variation has been suggested to be a risk factor for diabetes-related complications. Previous studies did not address confounding of diabetes duration, number of visits and length of follow-up. Here, we characterize glycemic variability over time and whether its relation to diabetes-related complications and mortality is independent from diabetes- and follow-up duration.
#1Ekaterini Lambrinou (CUT: Cyprus University of Technology)H-Index: 14
#2Tina Birgitte Hansen (University of Southern Denmark)H-Index: 9
Last.Joline W.J. Beulens (PHRI: Public Health Research Institute)H-Index: 50
view all 3 authors...
Although management of diabetes mellitus is improving, inadequately managed cases still exist. Prevention of diabetes mellitus requires an integrated and holistic approach based on the origin of th...