Thi Dan Linh Nguyen-Kim
University of Zurich
Publications 50
#1Thi Dan Linh Nguyen-Kim (UZH: University of Zurich)H-Index: 11
#2Stefano Trebeschi (NKI-AVL: Netherlands Cancer Institute)H-Index: 2
Last.Reinhard Dummer (UZH: University of Zurich)H-Index: 98
view all 13 authors...
Abstract Background Melanoma patients have shown sarcoid-like lesions as an immune-related adverse event to anti-PD-1 immunotherapy. Proper discrimination is essential for accurate treatment decision. Aim of the study is to distinguish granulomatous disease (GD) from pulmonary metastases (MET) and enlarged intrapulmonary lymph nodes (LN) in melanoma patients treated with immune checkpoint blockade by using deep learning. Methods Retrospective (2012-2018) analysis of 165 melanoma patients treated...
Background: To reduce the radiation exposure from chest computed tomography (CT), ultralow-dose CT (ULDCT) protocols performed at sub-millisievert levels were previously tested for the evaluation of pulmonary nodules (PNs). The purpose of our study was to investigate the effect of ULDCT and iterative image reconstruction on volumetric measurements of solid PNs. Methods: CT datasets of an anthropomorphic chest phantom containing solid microspheres were obtained with a third-generation dual-source...
#1Matthias Eberhard (UZH: University of Zurich)H-Index: 4
#2Daniel Stocker (UZH: University of Zurich)H-Index: 4
Last.Felix C. Tanner (UZH: University of Zurich)H-Index: 41
view all 11 authors...
Abstract Background Epicardial adipose tissue (EAT) is involved in inflammation and associated with cardiovascular risk factors. It is not known whether EAT affects outcome of patients undergoing transcatheter aortic valve replacement (TAVR). Methods 503 consecutive patients undergoing TAVR at our institution between May 2008 and November 2015 were enrolled in a prospective registry. Multi-detector computed tomography (CT) was used for EAT quantification. Outcome was assessed by 1-, 2-, and 3-ye...
1 CitationsSource
#1Zuhir Bodalal (UM: Maastricht University)H-Index: 2
#2Stefano Trebeschi (UM: Maastricht University)H-Index: 4
Last.Regina G. H. Beets-Tan (UM: Maastricht University)H-Index: 53
view all 5 authors...
From diagnostics to prognosis to response prediction, new applications for radiomics are rapidly being developed. One of the fastest evolving branches involves linking imaging phenotypes to the tumor genetic profile, a field commonly referred to as “radiogenomics.” In this review, a general outline of radiogenomic literature concerning prominent mutations across different tumor sites will be provided. The field of radiogenomics originates from image processing techniques developed decades ago; h...
3 CitationsSource
#1Matthias Eberhard (UZH: University of Zurich)H-Index: 4
#2Ricarda Hinzpeter (UZH: University of Zurich)H-Index: 5
Last.Hatem Alkadhi (UZH: University of Zurich)H-Index: 68
view all 9 authors...
Abstract Background To investigate whether aortic valve calcification (AVC) scoring performed with different workstation platforms generates comparable and thus software-independent results. Methods In this IRB-approved retrospective study, we included 100 consecutive patients with symptomatic aortic stenosis undergoing CT prior to transcatheter aortic valve implantation. Two independent observers performed AVC scoring on non-enhanced images with commercially available software platforms of four...
#1Matthias Eberhard (UZH: University of Zurich)H-Index: 4
#2Gianluca Milanese (University of Parma)H-Index: 3
Last.Thi Dan Linh Nguyen-Kim (UZH: University of Zurich)H-Index: 11
view all 9 authors...
Objectives To assess the value of pre-procedural computed tomography angiography (CTA) measurements of the suprahepatic inferior vena cava (IVC) to detect elevated central venous pressure (CVP) assessed by right heart catheterisation (RHC), and to predict post-procedural 1-year mortality in a cohort of patients undergoing transcatheter aortic valve implantation (TAVI).
#1Sabrina A. Hogan (UZH: University of Zurich)H-Index: 3
#2Anais CourtierH-Index: 4
Last.Mitchell P. Levesque (UZH: University of Zurich)H-Index: 24
view all 16 authors...
Many metastatic melanoma patients experience durable responses to anti-PD1 and/or anti-CTLA4; however, a significant proportion (over 50%) do not benefit from the therapies. In this study, we sought to assess pretreatment liquid biopsies for biomarkers that may correlate with response to checkpoint blockade. We measured the combinatorial diversity evenness of the T-cell receptor (TCR) repertoire (the DE50, with low values corresponding to more clonality and lack of TCR diversity) in pretreatment...
5 CitationsSource
Background: To evaluate usability of slice-reduced sequential computed tomography (CT) compared to standard high-resolution CT (HRCT) in patients with systemic sclerosis (SSc) for qualitative and quantitative assessment of interstitial lung disease (ILD) with respect to (I) detection of lung parenchymal abnormalities, (II) qualitative and semiquantitative visual assessment, (III) quantification of ILD by histograms and (IV) accuracy for the 20%-cut off discrimination. Methods: From standard ches...
2 CitationsSource
#1Patryk Kambakamba (UZH: University of Zurich)H-Index: 9
#2Michael Linecker (UZH: University of Zurich)H-Index: 13
Last.Mickael Lesurtel (UZH: University of Zurich)H-Index: 28
view all 11 authors...
Abstract Background Associating liver partition and portal vein ligation for staged hepatectomy induces an unprecedented liver hypertrophy and enables resection of otherwise unresectable liver tumors. The effect of associating liver partition and portal vein ligation for staged hepatectomy on tumor proliferation, however, remains a concern. This study investigated the impact of associating liver partition and portal vein ligation for staged hepatectomy on growth of colorectal metastases in mice ...
4 CitationsSource
#1Thomas Klikovits (Medical University of Vienna)H-Index: 13
#2Paul Stockhammer (Medical University of Vienna)H-Index: 2
Last.Balazs Hegedus (MTA: Hungarian Academy of Sciences)H-Index: 26
view all 18 authors...
Only limited information is available on the role of complement activation in malignant pleural mesothelioma (MPM). Thus, we investigated the circulating and tissue levels of the complement component 4d (C4d) in MPM. Plasma samples from 55 MPM patients, 21 healthy volunteers (HV) and 14 patients with non-malignant pleural diseases (NMPD) were measured by ELISA for C4d levels. Tissue specimens from 32 patients were analyzed by C4d immunohistochemistry. Tumor volumetry was measured in 20 patients....
6 CitationsSource