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Emanuele Di Angelantonio
University of Cambridge
243Publications
54H-index
19kCitations
Publications 248
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Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on detailed lipoprotein measures and compare those to genetic inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). We used an allele associated with lower CETP expression (rs247617) to mimic CETP inhibition and an allele associated with lower HMGCR expressio...
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Background: Evidence from randomized trials has shown that therapies that lower LDL (low-density lipoprotein)-cholesterol and triglycerides reduce coronary artery disease (CAD) risk. However, there...
Background - Evidence from randomized trials has shown that therapies that lower low-density lipoprotein (LDL)-cholesterol and triglycerides reduce coronary artery disease (CAD) risk. However, ther...
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Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 participants from UK Biobank, we identify 30 (29 previously unreported) independent-loci associated with income. Using a method to meta-analyze data from genetically-correlated traits, we identify an additional 120 income-associated loci. These loci show clear evidence of functionality, with transcriptional differences ide...
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#1Stephen KaptogeH-Index: 51
#2Lisa PennellsH-Index: 12
Last.Emanuele Di AngelantonioH-Index: 54
view all 101 authors...
Summary Background To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. Methods In this model revision initiative, we derived 10-year risk prediction models for fatal an...
1 CitationsSource
#1Stephen KaptogeH-Index: 51
Last.Jonathan MantH-Index: 45
view all 121 authors...
Summary Background The INTERVAL trial showed that, over a 2-year period, inter-donation intervals for whole blood donation can be safely reduced to meet blood shortages. We extended the INTERVAL trial for a further 2 years to evaluate the longer-term risks and benefits of varying inter-donation intervals, and to compare routine versus more intensive reminders to help donors keep appointments. Methods The INTERVAL trial was a parallel group, pragmatic, randomised trial that recruited blood donors...
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#1Luanluan Sun (University of Cambridge)
#2Lisa Pennells (University of Cambridge)H-Index: 12
Last.Emanuele Di Angelantonio (University of Cambridge)H-Index: 54
view all 21 authors...
Background: There is debate about the value of adding information on genetic and other molecular markers to conventional cardiovascular disease (CVD) risk predictors. Methods: Using data on 306,654 individuals without a history of CVD from UK Biobank, we calculated measures of risk-discrimination and reclassification upon addition of polygenic risk scores (PRS) and a panel of 27 clinical biochemistry markers to a conventional risk prediction model (i.e., including age, sex, systolic blood pressu...
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#1Veerle Dam (UU: Utrecht University)H-Index: 3
#2Y. T. van der Schouw (UU: Utrecht University)H-Index: 88
Last.Adam S. Butterworth (University of Cambridge)H-Index: 46
view all 49 authors...
Background: Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these associations are explained by established cardiovascular risk factors. Methods: We used data from EPIC-CVD...
2 CitationsSource
#1Barbora SilarovaH-Index: 6
#2Stephen J. SharpH-Index: 72
Last.Simon J. GriffinH-Index: 65
view all 15 authors...
This work was supported by a European Commission Framework 7 EPIC-CVD Grant agreement no: 279233. NHS Blood and Transplant funded the INTERVAL trial. DNA extraction and genotyping in INTERVAL/INFORM was funded by the National Institute for Health Research. The coordinating team for INTERVAL/INFORM at the Cardiovascular Epidemiology Unit of the University of Cambridge was supported by core funding from: UK Medical Research Council (G0800270), British Heart Foundation (SP/09/002), British Heart Fo...
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#1Barbora Silarova (University of Cambridge)H-Index: 6
#2Stephen J. Sharp (University of Cambridge)H-Index: 72
Last.Simon J. Griffin (University of Cambridge)H-Index: 65
view all 15 authors...
Objective To determine whether provision of web-based lifestyle advice and coronary heart disease risk information either based on phenotypic characteristics or phenotypic plus genetic characteristics affects changes in objectively measured health behaviours. Methods A parallel-group, open randomised trial including 956 male and female blood donors with no history of cardiovascular disease (mean [SD] age=56.7 [8.8] years) randomised to four study groups: control group (no information provided); ...
2 CitationsSource
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