Sylvane Desrivières
King's College London
Genome-wide association studyPsychiatryPsychologyGeneticsBiology
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Publications 160
#1Zuo Zhang ('KCL': King's College London)H-Index: 2
#2Lauren Robinson ('KCL': King's College London)H-Index: 1
Last. Arun L.W. Bokde (Trinity College, Dublin)H-Index: 42
view all 36 authors...
Abstract Background Eating disorders are common in adolescence, devastating and strongly comorbid with other psychiatric disorders. Yet, little is known about their etiology to develop effective preventive measures. Methods Longitudinal assessments of disordered eating behaviors (DEBs; binge-eating, purging and dieting) and comorbid psychopathology were measured in 1,386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems were investigated by comparing pa...
#1Amirhossein Modabbernia (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 23
#3Avi Reichenberg (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 54
Last. Andreas Becker (GAU: University of Göttingen)H-Index: 21
view all 36 authors...
Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available...
#1Nicholas Judd (KI: Karolinska Institutet)
#2Bruno Sauce (KI: Karolinska Institutet)H-Index: 7
Last. Corinna Insensee (University Medical Center)
view all 36 authors...
Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, and both have been associated with variations in brain structure and cognition. However, genetics and SES are correlated, and no prior study has assessed their neural associations independently. Here we used a polygenic score for educational attainment (EduYears-PGS), as well as SES, in a longitudinal study of 551 adolescents to tease apart genetic and environmental associations with brain de...
#1Han Bossier (UGent: Ghent University)H-Index: 2
#2Sanne Roels (UGent: Ghent University)H-Index: 5
Last. Antoine Grigis (Université Paris-Saclay)H-Index: 2
view all 25 authors...
Abstract Replicating results (i.e. obtaining consistent results using a new independent dataset) is an essential part of good science. As replicability has consequences for theories derived from empirical studies, it is of utmost importance to better understand the underlying mechanisms influencing it. A popular tool for non-invasive neuroimaging studies is functional magnetic resonance imaging (fMRI). While the effect of underpowered studies is well documented, the empirical assessment of the i...
1 CitationsSource
#1Rachel M. Brouwer (UU: Utrecht University)H-Index: 32
#2Marieke Klein (UCSD: University of California, San Diego)
Last. Nitin Gogtay (APA: American Psychological Association)
view all 195 authors...
Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. While heritable, specific loci in the genome that influence these rates are largely unknown. Here, we sought to find common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association analysis of longitudinal changes in brain morphology across the lifespan. Longitudinal ma...
#1Tianye JiaH-Index: 14
#2Alex Ing ('KCL': King's College London)H-Index: 3
Last. Uli BrombergH-Index: 18
view all 30 authors...
Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social–emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual be...
#1Tristram A. Lett (Charité)H-Index: 12
#2Bob O. Vogel (Charité)H-Index: 2
Last. Henrik Walter (Charité)H-Index: 60
view all 39 authors...
Recent large-scale, genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with general intelligence. The cumulative influence of these loci on brain structure is unknown. We examined if cortical morphology mediates the relationship between GWAS-derived polygenic scores for intelligence (PSi) and g-factor. Using the effect sizes from one of the largest GWAS meta-analysis on general intelligence to date, PSi were calculated among 10 P value thresholds. PSi were...
#1Dennis van der Meer (UM: Maastricht University)H-Index: 11
#2Ida E. Sønderby (Oslo University Hospital)H-Index: 8
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 89
view all 132 authors...
Importance Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. Objective To determine the association of the 15q11.2 BP...
5 CitationsSource
#1Gabriel RobertH-Index: 2
#2Qiang Luo (Fudan University)H-Index: 12
Last. Gunter SchumannH-Index: 51
view all 33 authors...
Importance Alcohol abuse correlates with gray matter development in adolescents, but the directionality of this association remains unknown. Objective To investigate the directionality of the association between gray matter development and increase in frequency of drunkenness among adolescents. Design, Setting, and Participants This cohort study analyzed participants of IMAGEN, a multicenter brain imaging study of healthy adolescents in 8 European sites in Germany (Mannheim, Dresden, Berlin, and...
1 CitationsSource
#1Paul M. Thompson (SC: University of Southern California)H-Index: 141
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Willem Bruin (UvA: University of Amsterdam)H-Index: 1
view all 169 authors...
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in ...
18 CitationsSource