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Silva A. Arslanian
University of Pittsburgh
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
302Publications
65H-index
15.6kCitations
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Publications 287
Newest
#1Suzanne CraftH-Index: 79
#2Mark TripputiH-Index: 1
Last. Kieren J. MatherH-Index: 39
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In cross-sectional studies, adolescents with T2D show poorer cognition than normoglycemic youth. In the Restoring Insulin Secretion (RISE) Study, we assessed longitudinal relationships between insulin sensitivity, β-cell function and cognition in 72 youth (mean age 14.3±2.0, 10-18 y) with IGT or recently diagnosed T2D, randomized to 12 months of metformin (MET) or 3 months of glargine followed by 9 months of metformin (G/M). Hyperglycemic clamps were used to measure insulin sensitivity and β-cel...
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#1Joon Young KimH-Index: 10
#1Jun-Young KimH-Index: 11
Last. Silva A. ArslanianH-Index: 65
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#1Silva A. ArslanianH-Index: 65
#2Laure El ghormliH-Index: 15
Last. Steven E. KahnH-Index: 100
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#1David A. EhrmannH-Index: 49
#2Sharon L. EdelsteinH-Index: 39
Last. Steven E. KahnH-Index: 100
view all 9 authors...
The RISE Consortium conducted a study in adults with IGT or recently diagnosed T2D to determine if β-cell function can be conserved or improved. Participants were randomized to GB, metformin, liraglutide + metformin (L+M), or placebo. β-cell function was assessed at baseline (BAS) and at 12 mo (12M) on therapy. Hyperglycemic clamp measures of β-cell function were: acute C-peptide (CP) response to glucose (ACPRg), steady-state CP (SSCP) at a plasma glucose of 11.1 mmol/L and maximal CP response t...
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#1Kieren J. MatherH-Index: 39
#2Ashley H. TjadenH-Index: 1
Last. Steven E. KahnH-Index: 100
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#1Aaron S. Kelly (UMN: University of Minnesota)H-Index: 29
#2Pernille Auerbach (Novo Nordisk)H-Index: 2
Last. Silva A. Arslanian (University of Pittsburgh)H-Index: 65
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#1Nour Y Gebara (Boston Children's Hospital)
#2Joon Young Kim (SU: Syracuse University)
Last. Silva A. Arslanian (Boston Children's Hospital)H-Index: 65
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#1Kumaravel Rajakumar (University of Pittsburgh)H-Index: 14
#2Charity G. Moore (University of Pittsburgh)H-Index: 46
Last. Steven E. Reis (University of Pittsburgh)H-Index: 53
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BACKGROUND: Obese children are vulnerable to vitamin D deficiency and impaired cardiovascular health; vitamin D replenishment might improve their cardiovascular health. OBJECTIVES: The aims were to determine, in vitamin D-deficient overweight and obese children, whether supplementation with vitamin D3 1000 or 2000 IU/d is more effective than 600 IU/d in improving arterial endothelial function, arterial stiffness, central and systemic blood pressure (BP), insulin sensitivity (1/fasting insulin co...
2 CitationsSource
BACKGROUND: Obesity is a chronic disease with limited treatment options in pediatric patients. Liraglutide may be useful for weight management in adolescents with obesity. METHODS: In this randomized, double-blind trial, which consisted of a 56-week treatment period and a 26-week follow-up period, we enrolled adolescents (12 to <18 years of age) with obesity and a poor response to lifestyle therapy alone. Participants were randomly assigned (1:1) to receive either liraglutide (3.0 mg) or placebo...
2 CitationsSource
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