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Silva A. Arslanian
University of Pittsburgh
283Publications
64H-index
14.8kCitations
Publications 285
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#1Joon Young Kim (SU: Syracuse University)
#2Hala Tfayli (AUB: American University of Beirut)H-Index: 18
Last.Silva A. Arslanian (Boston Children's Hospital)H-Index: 64
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#1Kumaravel Rajakumar (University of Pittsburgh)H-Index: 14
#2Charity G. Moore (University of Pittsburgh)H-Index: 46
Last.Steven E. Reis (University of Pittsburgh)H-Index: 52
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#1Sara F. Michaliszyn (YSU: Youngstown State University)H-Index: 9
#2Silva A. Arslanian (University of Pittsburgh)H-Index: 64
Insulin resistance is a central component to several important metabolic disorders and pathological conditions. Various methods are used to assess insulin sensitivity on both an individual level and epidemiological level. Several factors, such as validity, cost, and reproducibility, are important to the clinician and researcher in determining the most appropriate method. The insulin-clamp technique is considered the “gold standard” and provides the purest assessment of in vivo insulin sensitivit...
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#1Fida Bacha (BCM: Baylor College of Medicine)H-Index: 31
#2Laure El ghormli (GW: George Washington University)H-Index: 13
Last.Sarah A. Macleish (Case Western Reserve University)H-Index: 3
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#1Kristen J. NadeauH-Index: 30
#2Sharon L. EdelsteinH-Index: 39
Last.Tamara S. HannonH-Index: 12
view all 12 authors...
Identifying features of obese dysglycemic youth that predict deterioration of glucose homeostasis is key to planning interventions and future management. In RISE, we evaluated β-cell responses by hyperglycemic clamp and 3-h oral glucose tolerance testing (OGTT), and glycemic progression in 91 obese 10-19 year old youth with impaired glucose tolerance (IGT, 60%) or recent-onset type 2 diabetes (T2D, 40%). Outcomes were measured at baseline (BAS) and following 12 months (M12) of treatment with met...
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#1Meg H. Zeller (Cincinnati Children's Hospital Medical Center)H-Index: 35
#2Jennifer L. Brown (UC: University of Cincinnati)H-Index: 19
Last.Rachel AkersH-Index: 10
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Abstract Background Adolescents females with severe obesity are less likely to be sexually active, but those who are sexually active engage in risky sexual behaviors. Objectives To examine patterns and predictors of sexual risk behaviors, contraception practices, and sexual health outcomes in female adolescents with severe obesity who did or did not undergo bariatric surgery across 4 years. Setting Five academic medical centers. Methods Using a prospective observational controlled design, female...
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#1Suzanne CraftH-Index: 77
#2Amy ClaxtonH-Index: 10
Last.Philip ZeitlerH-Index: 30
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Insulin resistance and impaired β-cell function are associated with risk of cognitive decline in adults over 65 y of age. Their impact on cognition in youth and adults 25 mmol/L. The cognitive battery (CogState TM and story recall) assessed 1) psychomotor speed; 2) visual pattern separation; 3) visual attention and working memory; and 4) verbal learning and episodic memory. Linear regression models were fit to assess relationships between cognition and clamp measures by age group, adjusted for a...
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#2Andrea MariH-Index: 56
Last.Steven E. KahnH-Index: 98
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Results from hyperglycemic clamps in the Restoring Insulin Secretion (RISE) Study found that youth (10-19 y) with impaired glucose tolerance (IGT) or early type 2 diabetes (T2D) are more insulin resistant and secrete more insulin than adults (20-65 y), despite similar BMI. Here we use Mari modeling of RISE 3-h OGTT data to explore differences in β-cell function between youth and adults. The Mari model describes the relationship between insulin secretion rate (ISR) and glucose concentration. The ...
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#1Ashley H. TjadenH-Index: 1
#2Sharon L. EdelsteinH-Index: 39
Last.Steven E. KahnH-Index: 98
view all 11 authors...
Fasting and 2-h OGTT glucose along with HbA1c are used in clinical practice for diagnosing IGT and T2D, and in clinical trials for assessing eligibility. While previous studies found poor reproducibility of such measures in adults and youth at risk for dysglycemia, no studies have assessed group differences in reproducibility. We assessed reproducibility of glycemic measures in treatment-naive youth and adults screened for RISE. Central laboratory measurements of plasma glucose and HbA1c from tw...
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#2Andrea MariH-Index: 56
Last.Steven E. KahnH-Index: 98
view all 12 authors...
The Restoring Insulin Secretion (RISE) Study found that compared to adults (A), youth (Y) with early DM (33 Y, 104 A) or IGT (53 Y, 250 A) have higher insulin and C-peptide responses, even after adjusting for differences in insulin sensitivity. To better understand these differences, we compared mathematical modeling data from OGTTs to those from a hyperglycemic clamp within the RISE Study. Modeled measures were the dose-response relationship between glucose and insulin secretion (glucose sensit...
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