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Silva Arslanian
University of Pittsburgh
283Publications
62H-index
14kCitations
Publications 283
Newest
Published in Pediatric Diabetes 3.35
Fida Bacha31
Estimated H-index: 31
(BCM: Baylor College of Medicine),
Laure El ghormli13
Estimated H-index: 13
(GW: George Washington University)
+ -3 AuthorsSarah MacLeish2
Estimated H-index: 2
(Case Western Reserve University)
Published on Jun 1, 2019in Diabetes 7.20
Kristen J. Nadeau28
Estimated H-index: 28
,
Sharon L. Edelstein49
Estimated H-index: 49
+ 9 AuthorsMark Tripputi
Identifying features of obese dysglycemic youth that predict deterioration of glucose homeostasis is key to planning interventions and future management. In RISE, we evaluated β-cell responses by hyperglycemic clamp and 3-h oral glucose tolerance testing (OGTT), and glycemic progression in 91 obese 10-19 year old youth with impaired glucose tolerance (IGT, 60%) or recent-onset type 2 diabetes (T2D, 40%). Outcomes were measured at baseline (BAS) and following 12 months (M12) of treatment with met...
Published on Mar 1, 2019in Surgery for Obesity and Related Diseases 3.76
Meg H. Zeller33
Estimated H-index: 33
(Cincinnati Children's Hospital Medical Center),
Jennifer L. Brown19
Estimated H-index: 19
(UC: University of Cincinnati)
+ 35 AuthorsJennie G. Noll30
Estimated H-index: 30
(PSU: Pennsylvania State University)
Abstract Background Adolescents females with severe obesity are less likely to be sexually active, but those who are sexually active engage in risky sexual behaviors. Objectives To examine patterns and predictors of sexual risk behaviors, contraception practices, and sexual health outcomes in female adolescents with severe obesity who did or did not undergo bariatric surgery across 4 years. Setting Five academic medical centers. Methods Using a prospective observational controlled design, female...
Published on Jun 1, 2019in Diabetes 7.20
Suzanne Craft74
Estimated H-index: 74
,
Amy Claxton9
Estimated H-index: 9
+ 9 AuthorsBabak Mokhlesi36
Estimated H-index: 36
Insulin resistance and impaired β-cell function are associated with risk of cognitive decline in adults over 65 y of age. Their impact on cognition in youth and adults 25 mmol/L. The cognitive battery (CogState TM and story recall) assessed 1) psychomotor speed; 2) visual pattern separation; 3) visual attention and working memory; and 4) verbal learning and episodic memory. Linear regression models were fit to assess relationships between cognition and clamp measures by age group, adjusted for a...
Published on Jun 1, 2019in Diabetes 7.20
Kristina M. Utzschneider33
Estimated H-index: 33
,
Andrea Mari55
Estimated H-index: 55
+ 9 AuthorsThomas A. Buchanan70
Estimated H-index: 70
Results from hyperglycemic clamps in the Restoring Insulin Secretion (RISE) Study found that youth (10-19 y) with impaired glucose tolerance (IGT) or early type 2 diabetes (T2D) are more insulin resistant and secrete more insulin than adults (20-65 y), despite similar BMI. Here we use Mari modeling of RISE 3-h OGTT data to explore differences in β-cell function between youth and adults. The Mari model describes the relationship between insulin secretion rate (ISR) and glucose concentration. The ...
Published on Jun 1, 2019in Diabetes 7.20
Ashley H. Tjaden , Sharon L. Edelstein49
Estimated H-index: 49
+ 8 AuthorsAnny H. Xiang42
Estimated H-index: 42
Fasting and 2-h OGTT glucose along with HbA1c are used in clinical practice for diagnosing IGT and T2D, and in clinical trials for assessing eligibility. While previous studies found poor reproducibility of such measures in adults and youth at risk for dysglycemia, no studies have assessed group differences in reproducibility. We assessed reproducibility of glycemic measures in treatment-naive youth and adults screened for RISE. Central laboratory measurements of plasma glucose and HbA1c from tw...
Published on Jun 1, 2019in Diabetes 7.20
Kristina M. Utzschneider33
Estimated H-index: 33
,
Andrea Mari55
Estimated H-index: 55
+ 9 AuthorsThomas A. Buchanan70
Estimated H-index: 70
The Restoring Insulin Secretion (RISE) Study found that compared to adults (A), youth (Y) with early DM (33 Y, 104 A) or IGT (53 Y, 250 A) have higher insulin and C-peptide responses, even after adjusting for differences in insulin sensitivity. To better understand these differences, we compared mathematical modeling data from OGTTs to those from a hyperglycemic clamp within the RISE Study. Modeled measures were the dose-response relationship between glucose and insulin secretion (glucose sensit...
Published on Jun 1, 2019in Diabetes 7.20
Joon Young Kim5
Estimated H-index: 5
,
Nour Gebara + 2 AuthorsSilva Arslanian62
Estimated H-index: 62
The OGTT-GRCs [ I ncessant In crease (IIn), M ono ph asic (Mph), and B i ph asic (Bph)] reflect insulin sensitivity (IS) and β-cell function (BCF), being worse in the former and best in the latter. Accordingly, the prevalence of these GRCs differ in diabetic and nondiabetic individuals (Table). While islet cell Ab - obese youth CDX-T2D have worse IS, Ab + youth have severe impairment in BCF [Diabetes 58: 2009]. Here, we examined the prevalence of OGTT-GRC patterns, clamp-measured IS, and BCF in ...
Published on Jun 1, 2019in Diabetes 7.20
Tamara S. Hannon20
Estimated H-index: 20
,
Sharon L. Edelstein49
Estimated H-index: 49
+ 9 AuthorsMark Tripputi
The RISE Pediatric Medication Study showed, in 91 obese 10-19 yo youth with impaired glucose tolerance (IGT, 60%) or recent-onset type 2 diabetes (T2D, 40%), that 12 mo of intervention with metformin alone (M) or glargine for 3 mo followed by metformin for 9 mo (G+M) resulted in no change in BMI or HbA1c and a decline in β-cell function measured by hyperglycemic clamp. These outcomes worsened 3 mo after withdrawal of the interventions. We expand our findings to mo 21 (M21) post randomization (9 ...
Published on Apr 15, 2019
Nour Gebara (University of Pittsburgh), Joon Young Kim5
Estimated H-index: 5
(University of Pittsburgh)
+ 2 AuthorsSilva Arslanian62
Estimated H-index: 62
(University of Pittsburgh)
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