Simon Denley
Glasgow Royal Infirmary
OncologyPancreatic cancerAdenocarcinomaGeneral surgeryMedicine
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Publications 7
Clinical translation of immunohistochemistry (IHC) biomarkers requires reliable and reproducible cutoffs or thresholds for interpretation of immunostaining. Most IHC biomarker research focuses on the clinical relevance (diagnostic, prognostic, or predictive utility) of cutoffs, with less emphasis on observer agreement using these cutoffs. From the literature, we identified 3 commonly used cutoffs of 10% positive epithelial cells, 20% positive epithelial cells, and moderate to strong staining int...
#1Asif Ali (Glas.: University of Glasgow)H-Index: 3
#2Victoria Brown (Forth Valley Royal Hospital)H-Index: 1
Last. Karin A. Oien (Glas.: University of Glasgow)H-Index: 40
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Background: Pancreatico-biliary adenocarcinomas (PBA) have a poor prognosis. Diagnosis is usually achieved by imaging and/or endoscopy with confirmatory cytology. Cytological interpretation can be difficult especially in the setting of chronic pancreatitis/cholangitis. Immunohistochemistry (IHC) biomarkers could act as an adjunct to cytology to improve the diagnosis. Thus, we performed a meta-analysis and selected KOC, S100P, mesothelin and MUC1 for further validation in PBA resection specimens....
21 CitationsSource
#1Simon Denley (Glasgow Royal Infirmary)H-Index: 4
#2Nigel B. Jamieson (Glasgow Royal Infirmary)H-Index: 33
Last. Colin J. McKay (Glasgow Royal Infirmary)H-Index: 36
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Background and Objective Chronic localized pancreatic inflammation in the form of chronic pancreatitis is an established risk factor for human pancreatic ductal adenocarcinoma (PDAC) development. Constitutive activation of inflammation-related signal transducer and activator of transcription (Stat)3 signaling has been implicated in the development and progression a number of malignancies, including PDAC. Although, the Janus Kinase (Jak)/Stat pathway is a potential drug target, clinicopathologica...
46 CitationsSource
#1Nigel B. Jamieson (Glas.: University of Glasgow)H-Index: 33
#2Simon Denley (Glas.: University of Glasgow)H-Index: 4
Last. Donald C. McMillan (Glas.: University of Glasgow)H-Index: 69
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Background Outcome prediction after resection with curative intent for pancreatic ductal adenocarcinoma remains a challenge. There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor outcome in patients undergoing resection for a variety of common solid tumors. Our aim was to prospectively evaluate the prognostic value of tumor- and patient-related factors including the systemic inflammatory response in patients undergoing potentially cur...
64 CitationsSource
#1Colin J. McKayH-Index: 36
#2Simon DenleyH-Index: 4
Last. Ross CarterH-Index: 23
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1 CitationsSource
#1Simon Denley (Glasgow Royal Infirmary)H-Index: 4
#2Susan J. Moug (Glasgow Royal Infirmary)H-Index: 14
Last. Colin J. McKay (Glasgow Royal Infirmary)H-Index: 36
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Background and aims. The development of gastric outlet obstruction (GOO) in patients with advanced pancreatic cancer is regarded by some as a terminal event. There are several interventional options available, one of which is laparoscopic gastrojejunostomy (LGJ). To date, there are little data on the effectiveness of this intervention. Using patient records we sought to analyze our own experience of LGJ in patients with terminal pancreatic cancer.
9 CitationsSource
#1Simon DenleyH-Index: 4
#2Chris J. ShearerH-Index: 2
Last. Colin J. McKayH-Index: 36
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