Eugenia Dogliotti
Istituto Superiore di Sanità
DNA repairMolecular biologyBase excision repairGeneticsBiology
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Publications 163
Climate changes affect social and environmental health determinants such as clean air, ecosystems health, safe drinking water and safe sufficient food. Globally, people at greatest risk of adverse health effects associated with climate change include children, the elderly and other vulnerable groups. Temperature-related death and illness, extreme events, polluted or stressed ecosystems represent relevant issues raising concern for both health and economic consequences. The aim of the Symposium w...
#1Mahara Valverde (UNAM: National Autonomous University of Mexico)H-Index: 21
#2Jonathan Lozano-Salgado (UNAM: National Autonomous University of Mexico)
Last. Eugenia Dogliotti (ISS: Istituto Superiore di Sanità)H-Index: 41
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Human adipose-derived mesenchymal stem cells (hADMSCs) are recognized as a potential tool in cell tissue therapy because of their capacity to proliferate and differentiate in vitro. Several studies have addressed their use in regenerative medicine; however, little is known regarding their response to DNA damage and in particular to the reactive oxygen species (ROS) that are present in the microenvironment of implantation. In this study, we used the ROS-inducing agent hydrogen peroxide to explore...
#1Barbara PascucciH-Index: 18
#2Alessandra FragaleH-Index: 15
Last. Mariarosaria D’ErricoH-Index: 22
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// Barbara Pascucci 1, 3 , Alessandra Fragale 2 , Veronica Marabitti 3 , Giuseppe Leuzzi 3, 4 , Angelo Salvatore Calcagnile 3 , Eleonora Parlanti 3 , Annapaola Franchitto 3 , Eugenia Dogliotti 3 and Mariarosaria D’Errico 3 1 Institute of Cristallography, Consiglio Nazionale delle Ricerche, Roma, Italy 2 Section of Tumor Immunology, Department of Oncology and Molecular Medicine, Istituto Superiore di Sanita, Roma, Italy 3 Section of Mechanisms, Biomarkers and Models, Department of Environment and...
3 CitationsSource
#1Barbara Pascucci (ISS: Istituto Superiore di Sanità)H-Index: 18
#2Mariarosaria D’Errico (ISS: Istituto Superiore di Sanità)H-Index: 22
Last. Eugenia Dogliotti (ISS: Istituto Superiore di Sanità)H-Index: 41
view all 17 authors...
The ERCC8/CSA gene encodes a WD-40 repeat protein (CSA) that is part of a E3-ubiquitin ligase/COP9 signalosome complex. When mutated, CSA causes the Cockayne Syndrome group A (CS-A), a rare recessive progeroid disorder characterized by sun sensitivity and neurodevelopmental abnormalities. CS-A cells features include ROS hyperproduction, accumulation of oxidative genome damage, mitochondrial dysfunction and increased apoptosis that may contribute to the neurodegenerative process. In this study, w...
7 CitationsSource
#1Valeria Simonelli (ISS: Istituto Superiore di Sanità)H-Index: 9
#2Giuseppe Leuzzi (ISS: Istituto Superiore di Sanità)H-Index: 5
Last. Eugenia Dogliotti (ISS: Istituto Superiore di Sanità)H-Index: 41
view all 15 authors...
// Valeria Simonelli 1, * , Giuseppe Leuzzi 1, * , Giorgia Basile 1, * , Mariarosaria D’Errico 1 , Paola Fortini 1 , Annapaola Franchitto 1 , Valentina Viti 2 , Ashley R. Brown 3 , Eleonora Parlanti 1 , Barbara Pascucci 4 , Domenico Palli 5 , Alessandro Giuliani 1 , Fabio Palombo 6 , Robert W. Sobol 3, 7, 8 , Eugenia Dogliotti 1 1 Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Rome, Italy 2 Istituto di Ricerche Biologia Molecolare P. Angeletti (IRBM), Pomezia (Ro...
8 CitationsSource
#1Mariarosaria D’Errico (ISS: Istituto Superiore di Sanità)H-Index: 22
#2Eleonora Parlanti (ISS: Istituto Superiore di Sanità)H-Index: 16
Last. Eugenia Dogliotti (ISS: Istituto Superiore di Sanità)H-Index: 41
view all 7 authors...
Abstract Oxidative stress is associated with a growing number of diseases that span from cancer to neurodegeneration. Most oxidatively induced DNA base lesions are repaired by the base excision repair (BER) pathway which involves the action of various DNA glycosylases. There are numerous genome wide studies attempting to associate single-nucleotide polymorphisms (SNPs) with predispositions to various types of disease; often, these common variants do not have significant alterations in their bioc...
7 CitationsSource
#2Jan AlexanderH-Index: 50
Last. Christiane VleminckxH-Index: 10
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Erucic acid is the trivial name of the fatty acid cis-13-docosenoic acid and occurs at high concentrations mainly in the seeds of species of the Brassicaceae (e.g. rape seed or mustard seed). The European Commission requested EFSA to deliver a scientific opinion on the risks for animal and human health related to the presence of erucic acid in feed and food. For most humans, the main contributor to dietary exposure to erucic acid was the food group ‘Fine bakery wares’. In ‘Infants’, ‘Food for in...
31 CitationsSource
#1Eugenia Dogliotti (ISS: Istituto Superiore di Sanità)H-Index: 41
#1Emanuela Medda (ISS: Istituto Superiore di Sanità)H-Index: 20
#2Anna Minoprio (ISS: Istituto Superiore di Sanità)H-Index: 11
Last. Eugenia Dogliotti (ISS: Istituto Superiore di Sanità)H-Index: 41
view all 14 authors...
Abstract Inefficient response to oxidative stress has been associated with ageing and health risk. Metals are known to inhibit DNA repair and may modify the antioxidant response. How genetic variability and lifestyle factors modulate the response to oxidative stress is poorly explored. Our study aims to disentangle the contribution of genetics and environmental exposures to oxidative stress response using data from twin pairs. The non-enzymatic antioxidant capacity (NEAC), the repair capacity of...
1 CitationsSource