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Achuthan C. Raghavamenon
Southern University and A&M College
20Publications
5H-index
221Citations
Publications 20
Newest
Abstract A combination of fresh fruits adequately supplying required nutrients is likely to have better health benefits by virtue of the synergistic/additive effect of its natural constituents. With this view and aiming to obtain phenolic glycosides in combination, fresh apple, grape, orange, pomegranate, and sapota fruit juices were combined and lyophilized. An aqueous extract of this fruit combination (AEFC) had polyphenols as a major constituent (47.36 µ g GAE/mL) and LC-MS analysis documente...
Hepatosteatosis, a form of nonalcoholic fatty liver disease (NAFLD), is being increasingly recognized as a major health burden worldwide. Insulin resistance, dyslipidemia and imbalances in adipokine/cytokine interplay are reported to be involved in the onset and progression of this disease. Use of dietary nutraceuticals in prevention and treatment of NAFLD is emerging. Virgin coconut oil (VCO), a fermented product of fresh coconut kernel, has been shown to impede the development of hepatosteatos...
AbstractVirgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol content (VCOP), the mechanistic basis of which is less explored. Liquid chromatography/mass spectroscopy (LC/MS) analysis of VCOP ...
#1Achuthan C. Raghavamenon (SU: Southern University and A&M College)H-Index: 5
#2Akinniyi F. Muyiwa (SU: Southern University and A&M College)H-Index: 1
Last.Rao M. Uppu (SU: Southern University and A&M College)H-Index: 24
view all 4 authors...
The cytotoxicity of dihydroartemisinin (DHART; an active metabolite of artemisinin or ART) was investigated using murine GT1-7 hypothalamic neurons. A decrease in neuronal cell viability was observed in DHART-treated cells typically after 6 h of incubation. When neuronal cells were exposed to DHART for 24 h, the value of IC50 was found to be 24 ± 3.2 µM (n = 6). Based on acridine orange/ethidium bromide (dual) staining and increases in oligonucleosomal fragmentation, the cell death at lower conc...
#1Laura Laynes (SU: Southern University and A&M College)H-Index: 1
#2Achuthan C. Raghavamenon (SU: Southern University and A&M College)H-Index: 5
Last.Rao M. Uppu (SU: Southern University and A&M College)H-Index: 24
view all 5 authors...
Abstract 3β-Hydroxy-5,6-secocholestan-6-al (cholesterol secoaldehyde or ChSeco), an oxysterol known to be formed in ozone- and singlet oxygen-mediated oxidations of cholesterol, has been detected in the atherosclerotic plaque and in the brain of patients suffering from Alzheimer’s disease and Lewy body dementia. Previously, we have shown that, in H9c2 cardiomyoblasts, ChSeco induces oxidative stress followed by apoptosis involving both intrinsic and extrinsic signaling pathways. In the present s...
#1Kunju Sathishkumar (SU: Southern University and A&M College)H-Index: 17
#2Achuthan C. Raghavamenon (SU: Southern University and A&M College)H-Index: 5
Last.Rao M. Uppu (SU: Southern University and A&M College)H-Index: 24
view all 6 authors...
#1S. Parthasarathy (OSU: Ohio State University)H-Index: 70
#2Achuthan C. Raghavamenon (SU: Southern University and A&M College)H-Index: 5
Last.Nalini Santanam (Marshall University)H-Index: 31
view all 4 authors...
Oxidized low-density lipoprotein (Ox-LDL) has been studied for over 25 years. Numerous pro- and anti-atherogenic properties have been attributed to Ox-LDL. Yet, Ox-LDL has neither been defined nor characterized, as its components and composition change depending on its source, method of preparation, storage, and use. It contains unoxidized and oxidized fatty acid derivatives both in the ester and free forms, their decomposition products, cholesterol and its oxidized products, proteins with oxidi...
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