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Rosalind A. Eeles
The Royal Marsden NHS Foundation Trust
702Publications
93H-index
36.2kCitations
Publications 707
Newest
#1Tommy Nyberg (University of Cambridge)H-Index: 26
#2Debra Frost (University of Cambridge)H-Index: 30
Last.Antonis C. Antoniou (University of Cambridge)H-Index: 60
view all 32 authors...
Abstract Background BRCA1 and BRCA2 mutations have been associated with prostate cancer (PCa) risk but a wide range of risk estimates have been reported that are based on retrospective studies. Objective To estimate relative and absolute PCa risks associated with BRCA1/2 mutations and to assess risk modification by age, family history, and mutation location. Design, setting, and participants This was a prospective cohort study of male BRCA1 (n = 376) and BRCA2 carriers (n = 447) identified in cl...
1 CitationsSource
#1Tom Callender (UCL: University College London)
#2Mark Emberton (UCL: University College London)H-Index: 64
Last.Nora Pashayan (UCL: University College London)H-Index: 22
view all 7 authors...
Background The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55–69. Knowing how the potential benefits and harms of screening vary by an individual’s risk of developing prostate cancer could inform decision-making about screening at both an individual and population level. This modelling study examined the benefit–harm tradeoffs and the cost-effectiveness of a risk-tailored screening programme ...
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#1Elizabeth PageH-Index: 9
#2Elizabeth BancroftH-Index: 19
Last.Rosalind A. EelesH-Index: 93
view all 136 authors...
Abstract Background Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective To report the utility of PSA screening, PrCa incidence, positive predictive value of PSA, biopsy, and tumour characteristics after 3 yr of screening, by BRCA status. Design, setting, and participants Men aged 40–69 yr with a germline pathogenic BRC...
3 CitationsSource
#1Marco Matejcic (SC: University of Southern California)H-Index: 1
#2Ed Saunders (ICR: Institute of Cancer Research)H-Index: 23
Last.Christopher A. Haiman (SC: University of Southern California)H-Index: 82
view all 77 authors...
Correction to: Nature Communications; https://doi.org/10.1038/s41467-018-06863-1, published online 5 November 2018. The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
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#1Philip J. Law (ICR: Institute of Cancer Research)H-Index: 12
#2Maria Timofeeva (Medical Research Council)H-Index: 10
Last.Malcolm G. Dunlop (Medical Research Council)H-Index: 66
view all 98 authors...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene e...
4 CitationsSource
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Xia Jiang (KI: Karolinska Institutet)H-Index: 12
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
view all 333 authors...
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Xia Jiang (KI: Karolinska Institutet)H-Index: 12
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
view all 333 authors...
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#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Hilary K. Finucane (Broad Institute)H-Index: 29
Last.Sara Lindstroem (UW: University of Washington)H-Index: 46
view all 333 authors...
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
9 CitationsSource
#1Amit Sud (ICR: Institute of Cancer Research)H-Index: 9
#2Hauke ThomsenH-Index: 25
Last.Richard S. Houlston (ICR: Institute of Cancer Research)H-Index: 93
view all 91 authors...
The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.
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#1Jayaram Vijayakrishnan (ICR: Institute of Cancer Research)H-Index: 26
#2James B. Studd (ICR: Institute of Cancer Research)H-Index: 5
Last.Richard S. Houlston (ICR: Institute of Cancer Research)H-Index: 93
view all 95 authors...
The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this Article, the order of authors within the author list was incorrect. The PRACTICAL consortium was incorrectly listed after Richard S. Houlston and should have been listed after Nora...
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