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Floris Foijer
University Medical Center Groningen
63Publications
15H-index
880Citations
Publications 71
Newest
#1Klaske M Schukken (UG: University of Groningen)
Last.Holger BastiansH-Index: 14
view all 12 authors...
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that are aneuploid or exhibit a CIN phenotype. We find that aneuploid cells are much more sensitive to the energy metabolism regulating drug ZLN005 than their euploid counterparts. Furthermore, cells with an...
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#1Valentina Sladky (Innsbruck Medical University)H-Index: 3
#2Katja Knapp (Innsbruck Medical University)
Last.Eva Moreno (UU: Utrecht University)H-Index: 1
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Summary E2F transcription factors control the cytokinesis machinery and thereby ploidy in hepatocytes. If or how these proteins limit proliferation of polyploid cells with extra centrosomes remains unknown. Here, we show that the PIDDosome, a signaling platform essential for caspase-2-activation, limits hepatocyte ploidy and is instructed by the E2F network to control p53 in the developing as well as regenerating liver. Casp2 and Pidd1 act as direct transcriptional targets of E2F1 and its antago...
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1 CitationsSource
#1Pepijn M. Schoonen (UMCG: University Medical Center Groningen)H-Index: 4
#2Yannick P. Kok (UMCG: University Medical Center Groningen)H-Index: 1
Last.Marcel A.T.M. van Vugt (UMCG: University Medical Center Groningen)H-Index: 26
view all 7 authors...
Poly(ADP-ribose) polymerase (PARP) inhibitors are selectively cytotoxic in cancer cells with defects in homologous recombination (HR) (e.g., due to BRCA1/2 mutations). However, not all HR-deficient tumors efficiently respond to PARP inhibition and often acquire resistance. It is therefore important to uncover how PARP inhibitors induce cytotoxicity and develop combination strategies to potentiate PARP inhibitor efficacy in HR-deficient tumors. In this study, we found that forced mitotic entry up...
1 CitationsSource
#1Valentina SladkyH-Index: 3
Last.Andreas VillungerH-Index: 52
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Chromosomal instability (CIN) is an intricate phenomenon that is often found in human cancer, characterized by persisting errors in chromosome segregation. This ongoing chromosome mis-segregation results in structural and numerical chromosomal abnormalities that have been widely described to promote tumor evolution. In addition to being a driver of tumor evolution, recent evidence demonstrates CIN to be the central node of the crosstalk between a tumor and its surrounding microenvironment, as me...
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#1Michael Schubert (UMCG: University Medical Center Groningen)H-Index: 8
#2Maria Colomé-Tatché (TUM: Technische Universität München)H-Index: 14
Last.Floris Foijer (UMCG: University Medical Center Groningen)H-Index: 15
view all 3 authors...
Abstract Gene regulatory network inference is a standard technique for obtaining structured regulatory information from, for instance, gene expression measurements. Methods performing this task have been extensively evaluated on synthetic, and to a lesser extent real data sets. In contrast to these test evaluations, applications to gene expression data of human cancers are often limited by fewer samples and more potential regulatory links, and are biased by copy number aberrations as well as cel...
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#1Michael Schubert (UMCG: University Medical Center Groningen)H-Index: 8
Last.Floris Foijer (UMCG: University Medical Center Groningen)H-Index: 15
view all 3 authors...
Gene regulatory network inference is a standard technique for obtaining structured regulatory information from, among other data sources, gene expression measurements. Methods performing this task have been extensively evaluated on synthetic, and to a lesser extent real data sets. They are often applied to gene expression of human cancers. However, in contrast to the evaluations, these data sets often contain fewer samples, more potential regulatory links, and are biased by copy number aberratio...
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#1Nadeem ShaikhH-Index: 4
#2Alice MazzagattiH-Index: 2
Last.Sarah E. McClellandH-Index: 8
view all 11 authors...
Replication stress can drive genetic instability and is associated with chromosomal instability in cancer and during reprogramming of stem cells, however the exact mechanisms connecting replication stress to chromosome aberrations are not known. Here we use single cell DNA sequencing to precisely map DNA copy number alterations (CNAs) after one cell division cycle under replication stress in two diploid cell types to megabase pair resolution. Unexpectedly, we find that replication stress generat...
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#1Klaske M. Schukken (UMCG: University Medical Center Groningen)H-Index: 1
Last.Floris Foijer (UMCG: University Medical Center Groningen)H-Index: 15
view all 10 authors...
Chromosome instability (CIN) and aneuploidy are hallmarks of cancer. As the majority of cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that are aneuploid or exhibit a CIN phenotype. We find that aneuploid cells are much more sensitive to the energy metabolism regulating drug ZLN005 than their euploid counterparts. Furthermore, cel...
Source
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