EndocrinologyTestosteroneDiabetes mellitusMedicineBiology
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Publications 215
#1Marco InfanteH-Index: 2
#2Camillo RicordiH-Index: 83
Last. Rodolfo AlejandroH-Index: 48
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Recurrence of autoimmunity and allograft rejection represent major challenges that impact the success of islet transplantation. Despite the remarkable improvements achieved in immunosuppression strategies after the publication of the Edmonton protocol, long-term data of intra-hepatic islet transplantation show a gradual decline in beta-cell function. Therefore, there is a growing interest in the investigation of novel, safe and effective anti-inflammatory and immunomodulatory strategies able to ...
#1C AyeH-Index: 6
#2Matilde CalanchiniH-Index: 4
Last. Helen E. TurnerH-Index: 2
view all 8 authors...
#1Marco Infante (University of Rome Tor Vergata)H-Index: 1
#2Camillo RicordiH-Index: 83
Last. AndreaFabbri (University of Rome Tor Vergata)H-Index: 41
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Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses...
3 CitationsSource
#1Stefania GoriniH-Index: 8
Last. Massimiliano Caprio (OU: Open University)H-Index: 25
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The mineralocorticoid receptor (MR) was originally identified as a regulator of blood pressure, able to modulate renal sodium handling in response to its principal ligand aldosterone. MR is also expressed in many tissues other than kidney, including the heart, vasculature and adipose tissue. More recent studies have shown that extra-renal MR plays a relevant role in the control of cardiovascular and metabolic functions and has recently been implicated in the pathophysiology of aging. MR activati...
#1Matilde Calanchini (University of Oxford)H-Index: 1
#2Michael Tadman (University of Oxford)H-Index: 1
Last. Brian Shine (University of Oxford)H-Index: 19
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#1Andrea M. ArmaniH-Index: 20
#2Marco Infante (UM: University of Miami)H-Index: 1
Last. Massimiliano Caprio (OU: Open University)H-Index: 25
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#1Massimiliano Caprio (OU: Open University)H-Index: 25
#2Marco Infante (University of Rome Tor Vergata)H-Index: 2
Last. Andrea Lenzi (Sapienza University of Rome)H-Index: 57
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Background Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notab...
2 CitationsSource
#1Matilde CalanchiniH-Index: 4
#2AndreaFabbriH-Index: 41
Last. Helen E. TurnerH-Index: 2
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RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentiation/activation and calcium release from the skeleton, different studies have elucidated its specific role in mammary gland physiology and hormone-driven epithelial proliferation du...
1 CitationsSource