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Sean C. Bendall
Stanford University
119Publications
31H-index
8,332Citations
Publications 117
Newest
#1Felix J. Hartmann (Stanford University)H-Index: 10
#2Dunja Mrdjen (Stanford University)
Last.Sean C. Bendall (Stanford University)H-Index: 31
view all 11 authors...
Cellular metabolism regulates immune cell activation, differentiation and effector functions to the extent that its perturbation can augment immune responses. However, the analytical technologies available to study cellular metabolism lack single-cell resolution, obscuring metabolic heterogeneity and its connection to immune phenotype and function. To that end, we utilized high-dimensional, antibody-based technologies to simultaneously quantify the single-cell metabolic regulome in combination w...
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#1Bita Sahaf (Stanford University)H-Index: 14
#2Adeeb Rahman (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 16
Last.Sean C. Bendall (Stanford University)H-Index: 31
view all 4 authors...
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#1Felix J. Hartmann (Stanford University)H-Index: 10
#2Sean C. Bendall (Stanford University)H-Index: 31
The cellular complexity and functional diversity of the human immune system necessitate the use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such as rheumatic diseases, as well as other autoimmune and inflammatory disorders. Proteomic technologies that use elemental (heavy metal) reporter ions, such as mass cytometry (also known as CyTOF) and analogous high-dimensional imaging approaches (including multiplexed ion beam imaging (MIBI) and imaging mass cytomet...
1 CitationsSource
#1Samuel C. Kimmey (Stanford University)H-Index: 3
#2Luciene Borges (Stanford University)H-Index: 10
Last.Sean C. Bendall (Stanford University)H-Index: 31
view all 4 authors...
Cellular products derived from the activity of DNA, RNA, and protein synthesis collectively control cell identity and function. Yet there is little information on how these three biosynthesis activities are coordinated during transient and sparse cellular processes, such as activation and differentiation. Here, we describe Simultaneous Overview of tri-Molecule Biosynthesis (SOM3B), a molecular labeling and simultaneous detection strategy to quantify DNA, RNA, and protein synthesis in individual ...
4 CitationsSource
#1Loukia G. Karacosta (Stanford University)H-Index: 5
#2Benedict Anchang (Stanford University)H-Index: 6
Last.Sylvia K. Plevritis (Stanford University)H-Index: 38
view all 9 authors...
Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance. Using mass cytometry time-course analysis, we resolve lung cancer EMT states through TGFβ-treatment and identify, through TGFβ-withdrawal, a distinct MET state. We demonstrate significant differences between EMT and MET trajectories using a computational tool (TRACER) for reconstructing trajectories...
5 CitationsSource
#1Reema Baskar (Stanford University)H-Index: 1
#2Harris G. Fienberg (Stanford University)H-Index: 6
Last.Sean C. Bendall (Stanford University)H-Index: 31
view all 9 authors...
TNFα-related apoptosis-inducing ligand (TRAIL), specifically initiates programmed cell death, but often fails to eradicate all cells, making it an ineffective therapy for cancer. This fractional killing is linked to cellular variation that bulk assays cannot capture. Here, we quantify the diversity in cellular signaling responses to TRAIL, linking it to apoptotic frequency across numerous cell systems with single-cell mass cytometry (CyTOF). Although all cells respond to TRAIL, a variable fracti...
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#1Dunja Mrdjen (Stanford University)
#2Edward J. Fox (Stanford University)H-Index: 1
Last.Thomas J. Montine (Stanford University)H-Index: 81
view all 6 authors...
Alzheimer’s disease (AD) differentially and specifically affects brain regions and neuronal cell types in a predictable pattern. Damage to the brain appears to spread and worsens with time, taking over more regions and activating multiple stressors that can converge to promote vulnerability of certain cell types. At the same time, other cell types and brain regions remain intact in the face of this onslaught of neuropathology. Although neuropathologic descriptions of AD have been extensively exp...
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#1David R. Glass (Stanford University)
#2Albert Tsai (Stanford University)H-Index: 16
Last.Sean C. Bendall (Stanford University)H-Index: 31
view all 8 authors...
To evaluate the impact of heterogeneous B cells in health and disease, comprehensive profiling is needed at a single cell resolution. We developed a highly-multiplexed screen to quantify the co-expression of 351 surface molecules on low numbers of primary cells. We identified dozens of differentially expressed molecules and aligned their variance with B cell isotype usage, metabolism, biosynthesis activity, and signaling response. Here, we propose a new classification scheme to segregate periphe...
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