George Thanassoulis
McGill University
CardiologyDiseaseRisk factorDiabetes mellitusMedicine
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Publications 185
#1Jonathan Castiel (Lander University)
#2Annabel Chen-Tournoux (McGill University)H-Index: 15
Last. Michael Goldfarb (McGill University)H-Index: 9
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Abstract Background Screening relatives of patients with ischemic heart disease can identify over half of the population with poorly controlled cardiovascular (CV) risk factors. Family or household members (FMs) may be highly motivated to undergo CV primary prevention screening at the time of their relative’s admission to the Cardiovascular Intensive Care Unit (CICU). Methods Patients ≤70 years old admitted to a tertiary CICU for an acute coronary event were given a letter to refer FMs for CV sc...
#1Oscar Plunde (KI: Karolinska Institutet)
#2Susanna C. Larsson (KI: Karolinska Institutet)H-Index: 62
Last. Magnus Bäck (KI: Karolinska Institutet)H-Index: 34
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: Background - Aortic stenosis (AS) contributes to cardiovascular mortality and morbidity but disease mechanisms remain largely unknown. Recent evidence associates a single nucleotide polymorphism rs174547 within the FADS1 gene, encoding fatty acid desaturase 1, with risk of several cardiovascular outcomes, including AS. FADS1 encodes a rate-limiting enzyme for ω-3 and ω-6 fatty acid metabolism. The aim of this study was to decipher the local transcriptomic and lipidomic consequences of rs174547...
#1Ciaran N. Kohli-Lynch (Glas.: University of Glasgow)H-Index: 4
#2George Thanassoulis (MUHC: McGill University Health Centre)H-Index: 32
Last. Allan D. Sniderman (MUHC: McGill University Health Centre)H-Index: 67
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Abstract Background The ESC/EAS Guidelines and the EAS/EFLM consensus reports state that apoB is a more accurate marker of cardiovascular risk than LDL-C or non-HDL-C and that apoB can be measured accurately and precisely than LDL-C or non-HDL-C. Nevertheless, EAS/EFLM called for a randomized clinical trial and a cost-effective analysis before widespread implementation of apoB. Objective To analyse these issues from the perspective of clinical utility as clinical utility would be considered by a...
#1Christopher Labos (MUHC: McGill University Health Centre)H-Index: 10
#2George Thanassoulis (MUHC: McGill University Health Centre)H-Index: 32
#1Dennis T. KoH-Index: 48
#2Atul SivaswamyH-Index: 2
Last. George Thanassoulis (Libin Cardiovascular Institute of Alberta)
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BACKGROUND: Although accurate risk prediction is essential in guiding treatment decisions in primary prevention of atherosclerotic cardiovascular disease, the accuracy of the Framingham Risk Score (recommended by a Canadian guideline) and the Pooled Cohort Equations (recommended by US guidelines) has not been assessed in a large contemporary Canadian population. Our primary objective was to assess the calibration and discrimination of the Framingham Risk Score and Pooled Cohort Equations in Onta...
1 CitationsSource
#1Allan D. Sniderman (MUHC: McGill University Health Centre)H-Index: 67
#2George Thanassoulis (MUHC: McGill University Health Centre)H-Index: 32
Last. Michael J. Pencina (Duke University)H-Index: 88
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#1Mehdi AfsharH-Index: 2
#1Mehdi Afshar (McGill University)H-Index: 8
Last. Michael Y. TsaiH-Index: 57
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Oxidized phospholipids (OxPL) are carried by lipoprotein(a) (Lp(a)) and may contribute to Lp(a)-mediated aortic valve calcification (AVC). Plasma Lp(a) and OxPL were measured in the Multi-Ethnic Study of Atherosclerosis (n=4108) and the Framingham Heart Study (n=1143). AVC was quantified by cardiac
#1Hao Yu Chen (McGill University)H-Index: 3
#2Benjamin J Cairns (University of Oxford)H-Index: 25
Last. Richard Zhang (MUHC: McGill University Health Centre)H-Index: 1
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Importance Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways for AS could identify pharmacological targets. Objective To identify novel genetic loci and pathways associated with AS. Design, Setting, and Participants This genome-wide association study used a case-control design to evaluate 44 703 participants (3469 cases of AS) of self-reported European ancestry from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort (from January 1, 1...
1 CitationsSource
#1Tianyuan Lu (McGill University)H-Index: 1
Last. J. B. RichardsH-Index: 4
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BACKGROUND: Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide an opportunity to understand risk factors since they reflect etiologic pathways from the entire genome. We therefore tested whether a PRS for CHD influenced risk of CHD in individuals with type 2 diabetes and which risk factors were associated with this PRS. METHODS: We tested the association of a CHD PRS with CHD and its traditi...