Ravi Varadhan
Johns Hopkins University
Publications 126
#1Philip H. ImusH-Index: 2
#2Hua-Ling Tsai (Johns Hopkins University)H-Index: 10
Last.Richard J. JonesH-Index: 74
view all 16 authors...
Hematologic malignancies in older people are unlikely to be cured with chemotherapy alone. Advances in allogeneic blood or marrow transplantation (alloBMT), especially nonmyeloablative (NMA) conditioning and the use of haploidentical donors, now make this therapy available to older people; however, long-term outcomes and predictors of success are unclear. We reviewed the outcomes of 93 consecutive patients aged 70 and older (median, 72; range, 70-78), who underwent haploidentical BMT at Johns Ho...
#1Abdulla Damluji (Johns Hopkins University)H-Index: 9
#2Jin Huang (Johns Hopkins University)H-Index: 9
Last.Jodi B. Segal (Johns Hopkins University)H-Index: 51
view all 10 authors...
#1Karen Bandeen-Roche (Johns Hopkins University)H-Index: 65
#2Alden L. Gross (Johns Hopkins University)H-Index: 25
Last.Qian-Li Xue (Johns Hopkins University)H-Index: 25
view all 14 authors...
While generic drugs offer a cost-effective alternative to brand name drugs, regulators need a method to assess therapeutic equivalence in a post market setting. We develop such a method in the context of assessing the therapeutic equivalence of immediate release (IM) venlafaxine, based on a large insurance claims dataset provided by OptumLabs\textsuperscript{\textregistered}. To properly address this question, our methodology must deal with issues of non-adherence, secular trends in health outco...
#1Nicholas C. Henderson (Johns Hopkins University)H-Index: 4
#2Ravi Varadhan (Johns Hopkins University)H-Index: 24
AbstractThe expectation-maximization (EM) algorithm is a well-known iterative method for computing maximum likelihood estimates in a variety of statistical problems. Despite its numerous advantages...
4 CitationsSource
#1Amal A. Wanigatunga (Johns Hopkins University)H-Index: 7
#2Ravi Varadhan (Johns Hopkins University)H-Index: 24
Last.Jennifer A Schrack (Johns Hopkins University)H-Index: 19
view all 7 authors...
3 CitationsSource
#1Chenkai Wu (OSU: Oregon State University)H-Index: 5
#2Dae Hyun Kim (Brigham and Women's Hospital)H-Index: 32
Last.Michelle C. Odden (OSU: Oregon State University)H-Index: 26
view all 6 authors...
4 CitationsSource
#1Ravi Varadhan (Johns Hopkins University)H-Index: 24
#2D. W. Russ (OU: Ohio University)
Last.Linda P. Fried (Columbia University)H-Index: 120
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Background Physical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight loss, and/or exhaustion. Frail older adults often report that their major problem is “low energy”, and there is indirect evidence to support the hypothesis that frailty is a syndrome of dysregulated energetics. We hypothesized that altered cellular energy production underlies compromised response to stressors in the frail.
#1Abdulla Damluji (Johns Hopkins University)H-Index: 9
#2Karen Bandeen-RocheH-Index: 65
Last.Jodi B. SegalH-Index: 51
view all 10 authors...
The objective of this study was to estimate the prevalence of frailty among older adults (≥ 75 years) during AMI admission and examine the relationship between frailty and intervention. In Premier database, we classified individuals as frail or not using the validated Claims-based Frailty Index (