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Jay N. Giedd
University of California, San Diego
Developmental psychologyMagnetic resonance imagingPsychologyNeuroscienceNeuroimaging
311Publications
103H-index
48.7kCitations
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Publications 311
Newest
#2Jakob Seidlitz (University of Cambridge)H-Index: 10
Last. Armin RaznahanH-Index: 31
view all 8 authors...
Sex chromosome dosage (SCD) variation increases risk for neuropsychiatric impairment, which may reflect direct SCD effects on brain organization. Here, we 1) map cumulative X- and Y-chromosome dosage effects on regional cortical thickness (CT) and investigate potential functional implications of these effects using Neurosynth, 2) test if this map is organized by patterns of CT covariance that are evident in health, and 3) characterize SCD effects on CT covariance itself. We modeled SCD effects o...
2 CitationsSource
#1J. Eric Schmitt (HUP: Hospital of the University of Pennsylvania)H-Index: 24
#2Armin RaznahanH-Index: 31
Last. Michael C. Neale (VCU: Virginia Commonwealth University)H-Index: 69
view all 8 authors...
2 CitationsSource
#1Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 67
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 15
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 127
view all 143 authors...
Abstract The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other o...
15 CitationsSource
#1Jay N. Giedd (UCSD: University of California, San Diego)H-Index: 103
Source
#1J. Eric Schmitt (HUP: Hospital of the University of Pennsylvania)H-Index: 24
#2Michael C. Neale (VCU: Virginia Commonwealth University)H-Index: 69
Last. Armin RaznahanH-Index: 31
view all 11 authors...
The genetics of cortical arealization in youth is not well understood. In this study, we use a genetically-informative sample of 677 typically-developing children and adolescents (mean age 12.72 years), high-resolution MRI, and quantitative genetic methodology in order to address several fundamental questions on the genetics of cerebral surface area. We estimate that over 85% of the phenotypic variance in total brain surface area in youth is attributable to additive genetic factors. We also obse...
2 CitationsSource
#1Donald J. Hagler (UC: University of California)H-Index: 67
#2Sean N. Hatton (UC: University of California)H-Index: 15
Last. Anders M. Dale (UC: University of California)H-Index: 127
view all 142 authors...
The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The ABCD Study is a collaborative effort, including a Coordinating Center, 21 data acquisition sites across the United States, and a Data Analysis and Informatics Center (DAIC). The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to...
20 CitationsSource
Source
#1J. Eric Schmitt (HUP: Hospital of the University of Pennsylvania)H-Index: 24
#2Jay N. Giedd (UCSD: University of California, San Diego)H-Index: 103
Last. Michael C. Neale (VCU: Virginia Commonwealth University)H-Index: 69
view all 4 authors...
Although prior studies have demonstrated that genetic factors play the dominant role in the patterning of the pediatric brain, it remains unclear how these patterns change over time. Using 1748 longitudinal anatomic MRI scans from 792 healthy twins and siblings, we quantified how genetically mediated inter-regional associations change over time via multivariate longitudinal structural equation modeling. These analyses found that genetic correlations for both lobar volumes and cortical thickness ...
4 CitationsSource
#1Lara M. Wierenga (LEI: Leiden University)H-Index: 4
#2Joseph Sexton (University of Oslo)H-Index: 13
Last. Christian K. Tamnes (University of Oslo)H-Index: 32
view all 5 authors...
19 CitationsSource
#1Armin Raznahan (NIH: National Institutes of Health)H-Index: 31
#2Neelroop N. Parikshak (UCLA: University of California, Los Angeles)H-Index: 26
Last. Daniel H. Geschwind (UCLA: University of California, Los Angeles)H-Index: 129
view all 15 authors...
A fundamental question in the biology of sex differences has eluded direct study in humans: How does sex-chromosome dosage (SCD) shape genome function? To address this, we developed a systematic map of SCD effects on gene function by analyzing genome-wide expression data in humans with diverse sex-chromosome aneuploidies (XO, XXX, XXY, XYY, and XXYY). For sex chromosomes, we demonstrate a pattern of obligate dosage sensitivity among evolutionarily preserved X-Y homologs and update prevailing the...
21 CitationsSource
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