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András Gézsi
Semmelweis University
Single-nucleotide polymorphismImmunologyGeneticsMedicineBiology
40Publications
7H-index
177Citations
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Publications 43
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#1Anett Illés (Semmelweis University)H-Index: 2
#2Peter Balicza (Semmelweis University)H-Index: 4
Last. Mária Judit Molnár (Semmelweis University)H-Index: 14
view all 8 authors...
The protein product of the nuclear-encoded POLG gene plays a key role in the maintenance of mitochondrial DNA replication, and its failure causes multi-system diseases with varying severity. The clinical spectrum is extremely wide, and the most common symptoms include ptosis, myoclonus, epilepsy, myopathy, sensory ataxia, parkinsonism, cognitive decline and infertility. Now, it is known that mitochondrial dysfunction in Parkinson's disease plays a key role in the loss of dopaminergic neurons in ...
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#1Zsofia Gal (Semmelweis University)H-Index: 2
#2András Gézsi (Semmelweis University)H-Index: 7
Last. Gabriella GálffyH-Index: 10
view all 11 authors...
A flow cytometry-based method was developed to quantify in vivo circulating neutrophil extracellular trap (NET) levels in plasma and compare them in patients with different chronic inflammatory lung diseases. Seventeen asthmatic and 11 control children, 12 adult controls, 46 asthmatic, 6 COPD and 6 adult patients with asthma-COPD overlap syndrome (ACOS) were recruited in the study. The presence of NETs in unstimulated cell-free plasma was confirmed and visualized by confocal laser-scanning micro...
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Tie2, coded by the TEK gene, is a tyrosine kinase receptor and plays a central role in vascular stability. It was suggested that variations in the TEK gene might influence the susceptibility to asthma and allergic conjunctivitis. The aim of this study was to further investigate these suggestions, involving different populations and to study the Tie2 related pathway on a mouse model of asthma. The discovery, stage I cohort involved 306 patients with moderate and severe allergic rhinitis, the stag...
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#1Anett Illés (Semmelweis University)H-Index: 2
#2Dora Csabán (Semmelweis University)H-Index: 1
Last. Mária Judit Molnár (Semmelweis University)H-Index: 14
view all 10 authors...
The genetic analysis of early-onset Parkinsonian disorder (EOPD) is part of the clinical diagnostics. Several genes have been implicated in the genetic background of Parkinsonism, which is clinically indistinguishable from idiopathic Parkinson’s disease. The identification of patient’s genotype could support clinical decision-making process, also track and analyse outcomes in a comprehensive fashion. The aim of our study was to analyse the genetic background of EOPD in a Hungarian cohort and to ...
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#1Bálint Egyed (Semmelweis University)H-Index: 1
#2Judit C. Sági (Semmelweis University)H-Index: 3
Last. Ágnes F. Semsei (Semmelweis University)H-Index: 15
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#1Andrea Rzepiel (Semmelweis University)H-Index: 1
#2Nóra Kutszegi (Semmelweis University)H-Index: 6
Last. Dániel J. Erdélyi (Semmelweis University)H-Index: 11
view all 8 authors...
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#1Judit C. Sági (Semmelweis University)H-Index: 3
#2Anna Artner (Semmelweis University)
Last. Ágnes F. Semsei (Semmelweis University)H-Index: 15
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#1András Gézsi (BME: Budapest University of Technology and Economics)H-Index: 7
#2Árpád Ferenc Kovács (Semmelweis University)H-Index: 2
Last. Edit I. Buzás (Semmelweis University)H-Index: 41
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Extracellular vesicles (EVs) are membrane-enclosed structures secreted by cells. In the past decade, EVs have attracted substantial attention as carriers of complex intercellular information. They have been implicated in a wide variety of biological processes in health and disease. They are also considered to hold promise for future diagnostics and therapy. EVs are characterized by a previously underappreciated heterogeneity. The heterogeneity and molecular complexity of EVs necessitates high-th...
1 CitationsSource
#1Kata CzirbeszH-Index: 2
#2Eszter GorkaH-Index: 1
Last. Gabriella LiszkayH-Index: 10
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BRAF inhibitor vemurafenib achieved improved overall survival over chemotherapy and have been approved by the FDA and EMA for the treatment of BRAF-mutated metastatic melanoma. The aim of our retrospective analysis was to determine the efficacy and safety of vemurafenib therapy for BRAF mutated metastatic melanoma and subsequently to prove the clinical benefit for the studied 43 patients, based on real-life data. From November 2012 to October 2015 we have selected 43 BRAF mutated, metastatic mel...
1 CitationsSource
#1Anikó GálH-Index: 9
#2Shamim NaghdiH-Index: 10
Last. György HajnóczkyH-Index: 58
view all 6 authors...
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