David C. Christiani
Harvard University
CancerLung cancerMedicineBiologyEnvironmental health
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Publications 1145
#1Xuemei Ji (Dartmouth College)H-Index: 3
#2Semanti Mukherjee (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 16
Last. Olga Y. Gorlova (Dartmouth College)H-Index: 23
view all 111 authors...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2.22 × 10−3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and re...
#1Fan-Yun Lan (Harvard University)
#2Chih-Fu Wei (Harvard University)
Last. Stefanos N. Kales (Harvard University)H-Index: 33
view all 5 authors...
Importance: Our study helps fill the knowledge gap related to work-related transmission in the emerging coronaviral pandemic. Objective: To demonstrate high-risk occupations for early coronavirus disease 2019 (Covid-19) local transmission. Methods: In this observational study, we extracted confirmed Covid-19 cases from governmental investigation reports in Hong Kong, Japan, Singapore, Taiwan, Thailand, and Vietnam. We followed each country/area for 40 days after its first locally transmitted cas...
#1Yuzhuo Wang (Nanjing Medical University)H-Index: 5
#2Olga Y. Gorlova (BCM: Baylor College of Medicine)H-Index: 23
Last. Gary E. Goodman (Fred Hutchinson Cancer Research Center)H-Index: 49
view all 43 authors...
Background: A substantial proportion of cancer driver genes (CDGs) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated. Methods: We selected expression-related single nucleotide polymorphisms (eSNPs) and nonsynonymous variants of lung CDGs, and tested their associations with lung cancer risk in two large-scale genome-wide association studies (20,871 cases and 15,971 controls of E...
#1Barrett M. Welch (OSU: Oregon State University)H-Index: 1
#2Adam J. Branscum (OSU: Oregon State University)H-Index: 15
Last. Omar I.A. SharifH-Index: 1
view all 14 authors...
BACKGROUND: Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and manganese, to humoral immunity as measured by antibody concentrations to diphtheria and tetanus toxoid among vaccinated Bangladeshi children. Additionally, we examined if this association was potentially mediated by nutritional status. METHODS: Antibody concentrations to diphther...
#1Hae-Ryung Park (Harvard University)H-Index: 2
#2Ryan Sun (Harvard University)H-Index: 3
Last. Quan Lu (Harvard University)H-Index: 20
view all 5 authors...
Arsenic (As) exposure adversely affects neurodevelopment in children. Accumulation of misfolded proteins in cells exposed to As leads to endoplasmic reticulum (ER) stress response, which, if not relieved, results in cell death. Despite the potential role of ER stress for As-induced neurotoxicity, the underlying mechanisms remain poorly understood. Here we aimed to investigate the roles of microRNA(miR)-124, a novel ER stress suppressor, in As-induced ER stress response and cytotoxicity in neural...
#1Yohan Bossé (Laval University)H-Index: 39
#2Zhonglin Li (Laval University)H-Index: 1
Last. James D. McKay (IARC: International Agency for Research on Cancer)H-Index: 51
view all 48 authors...
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of this study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n=1,038) to identify candidate causal genes for lung cancer. We performed transcriptome-wide association study (TWAS) for lung cancer overall, by histology (adenocarcinoma, squamous cell carcinoma, small cell...
#1Wei Deng (Guangxi Medical University)
#1Qingyi Wei (Duke University)H-Index: 76
Last. David C. Christiani (Harvard University)H-Index: 85
view all 9 authors...
BACKGROUND: Several oncogenic signals are involved in the synthesis, metabolism, transportation and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain unclear. METHODS: We investigated associations between 26,781 common single-nucleotide polymorphisms (SNPs) in 209 genes of the cholesterol pathway and non-small cell lung cancer (NSCLC) survival by utilizing genotyping datasets from two published genome-wide association stu...
#1Mulong Du (Nanjing Medical University)
#2Guoshuai Cai (USC: University of South Carolina)H-Index: 1
Last. Meilin Wang (Nanjing Medical University)H-Index: 34
view all 6 authors...
2 CitationsSource
#1Elizabeth Loehrer (Harvard University)H-Index: 6
#2Edward Giovannucci (Harvard University)H-Index: 180
Last. David C. Christiani (Harvard University)H-Index: 85
view all 5 authors...
BACKGROUND: We examined whether body mass index (BMI) changes in adulthood, prior to disease onset, are associated with overall survival among esophageal adenocarcinoma patients. METHODS: We included 285 histologically confirmed patients with a complete baseline BMI questionnaire. Using extended Cox regression models, we obtained adjusted hazard ratios (HRs) for the associations between overall survival and BMI at diagnosis, BMI 6 months before diagnosis, self-reported average adult BMI, and Del...