David C. Christiani
Harvard University
Publications 1129
#1Crystal M. North (Harvard University)H-Index: 3
#2Piers MacNaughton (Harvard University)H-Index: 10
Last.Joseph G. Allen (Harvard University)H-Index: 19
view all 10 authors...
Most of the global burden of pollution-related morbidity and mortality is believed to occur in resource-limited settings, where HIV serostatus and sex may influence the relationship between air pollution exposure and respiratory morbidity. The lack of air quality monitoring networks in these settings limits progress in measuring global disparities in pollution-related health. Personal carbon monoxide monitoring may identify sub-populations at heightened risk for air pollution-associated respirat...
#1Zhaozhong Zhu (Harvard University)H-Index: 4
#2Xiao-Fang Wang (Zhengzhou University)H-Index: 6
Last.Liming Liang (Harvard University)H-Index: 49
view all 10 authors...
Background A growing number of studies clearly demonstrate a substantial association between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD), although little is known about the shared genetics that contribute to this association.
#1Yannick Berker (DKFZ: German Cancer Research Center)
#2Lindsey A. Vandergrift (Harvard University)H-Index: 3
Last.Eugene J. Mark (Harvard University)H-Index: 52
view all 10 authors...
Low-dose CT has shown promise in detecting early stage lung cancer. However, concerns about the adverse health effects of radiation and high cost prevent its use as a population-wide screening tool. Effective and feasible screening methods to triage suspicious patients to CT are needed. We investigated human lung cancer metabolomics from 93 paired tissue-serum samples with magnetic resonance spectroscopy and identified tissue and serum metabolomic markers that can differentiate cancer types and ...
#1Cheng Kuan Lin (Harvard University)H-Index: 1
#2Ro-Ting Lin (PRC: China Medical University (PRC))H-Index: 2
Last.David C. Christiani (Harvard University)H-Index: 83
view all 6 authors...
Background Exposure to ambient particulate matter generated from coal-fired power plants induces long-term health consequences. However, epidemiologic studies have not yet focused on attributing these health burdens specifically to energy consumption, impeding targeted intervention policies. We hypothesize that the generating capacity of coal-fired power plants may be associated with lung cancer incidence at the national level.
#1Pi-I D. Lin (Harvard University)H-Index: 1
#2Sabri Bromage (Harvard University)H-Index: 4
Last.David C. Christiani (Harvard University)H-Index: 83
view all 8 authors...
Background Epidemiological evidence suggests that arsenic (As) exposure during pregnancy may reduce infant birth weight. One significant source of As exposure is diet; thus, As may indirectly affect infant growth by mediating the effect of maternal diet on birth weight (BW). This study evaluated the potential mediating effect of As in the relationship between maternal diet and BW, gestational age (GA), and gestational weight gain (GWG).
#1Hongkun Park (Harvard University)H-Index: 49
#2Michael J. O'Sullivan (Harvard University)H-Index: 1
Last.David C. Christiani (Harvard University)H-Index: 83
view all 10 authors...
The widespread use of electronic cigarettes (e-cigarettes or e-cig) is a growing public health concern. Diacetyl and its chemical cousin 2,3-pentanedione are commonly used to add flavors to e-cig; however, little is known about how the flavoring chemicals may impair lung function. Here we report that the flavoring chemicals induce transcriptomic changes and perturb cilia function in the airway epithelium. Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in prima...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Joe Dennis (University of Cambridge)H-Index: 37
view all 10 authors...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Karoline Kuchenbaecker (UCL: University College London)H-Index: 3
view all 10 authors...
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Juncheng Dai (Nanjing Medical University)H-Index: 31
#2Jun Lv (PKU: Peking University)H-Index: 15
Last.Jingyi Fan (Nanjing Medical University)
view all 10 authors...
Summary Background Genetic variation has an important role in the development of non-small-cell lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully identified, especially in Chinese populations, which limits the use of existing polygenic risk scores (PRS) to identify subpopulations at high risk of lung cancer for prevention. We therefore aimed to identify novel loci associated with NSCLC risk, and generate a PRS and evaluate its utility and effectiveness in the pred...
#1Matthew J. Mazzella (ISMMS: Icahn School of Medicine at Mount Sinai)
#2Susan Sumner (UNC: University of North Carolina at Chapel Hill)H-Index: 27
Last.Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
view all 10 authors...
With advances in technologies that facilitate metabolome-wide analyses, the incorporation of metabolomics in the pursuit of biomarkers of exposure and effect is rapidly evolving in population health studies. However, many analytic approaches are limited in their capacity to address high-dimensional metabolomics data within an epidemiologic framework, including the highly collinear nature of the metabolites and consideration of confounding variables. In this Children’s Health Exposure Analysis Re...