Prabhu Srinivas Yavvari
Indian Institute of Science Education and Research, Bhopal
Publications 13
#1Sanjay Pal (KIIT: KIIT University)H-Index: 2
#2Nihal Medatwal (Manipal University)H-Index: 2
Last.Avinash BajajH-Index: 22
view all 18 authors...
Rapid proliferation of cancer cells assisted by endothelial cell-mediated angiogenesis and acquired inflammation at the tumor microenvironment (TME) lowers the success rate of chemotherapeutic regimens. Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiprolife...
2 CitationsSource
#1Kavita Yadav (Manipal University)H-Index: 3
#2Prabhu Srinivas Yavvari (Indian Institute of Science Education and Research, Bhopal)H-Index: 5
Last.Avinash BajajH-Index: 22
view all 15 authors...
A major impediment to develop effective antimicrobials against Gram-negative bacteria like Salmonella is the ability of the bacteria to develop resistance against existing antibiotics and inability of the antimicrobials to clear the intracellular bacteria residing in the gastrointestinal tract. As critical balance of charge and hydrophobicity is required for effective membrane-targeting antimicrobials without causing any toxicity to mammalian cells, herein we report the synthesis and antibacteri...
1 CitationsSource
#1Kavita Yadav (Manipal University)H-Index: 3
#2Sandeep Kumar (Manipal University)H-Index: 4
Last.Avinash BajajH-Index: 22
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The presence of lipopolysaccharide and emergence of drug resistance make the treatment of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis and antibacterial activities of cholic acid–peptide conjugates (CAPs), demonstrating that valine–glycine dipeptide-derived CAP 3 is the most effective antimicrobial. Molecular dynamics simulations and structural analysis revealed that a precise intramolecular network of CAP 3 is maintained in the form of evolving edges, ...
2 CitationsSource
#1Prabhu Srinivas Yavvari (IISc: Indian Institute of Science)H-Index: 5
#2Anand Kumar Awasthi (IISc: Indian Institute of Science)H-Index: 1
Last.Aasheesh Srivastava (IISc: Indian Institute of Science)H-Index: 16
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Polyelectrolytes (PELs) – polymers with charged repeat units – have emerged as a useful class of polymers for biomedical applications due to their high aqueous solubility, low aggregation propensity and the opportunity they afford for polyvalent interactions with surfaces. Biodegradability and biocompatibility of PELs are important prerequisites for their utilization in in vivo applications. PELs that can be chemically functionalized with ease prove advantageous for creating diverse biomaterials...
1 CitationsSource
#1Prabhu Srinivas Yavvari (Indian Institute of Science Education and Research, Bhopal)H-Index: 5
#2Priyanka VermaH-Index: 1
Last.Avinash BajajH-Index: 22
view all 10 authors...
Poor success rates and challenges associated with the current therapeutic strategies of inflammatory bowel disease (IBD) have accelerated the emergence of gene therapy as an alternative treatment option with great promise. However, oral delivery of nucleic acids (NAs) to an inflamed colon is challenged by multiple barriers presented by the gastrointestinal, extracellular and intracellular compartments. Therefore, we screened a series of polyaspartic acid-derived amphiphilic cationic polymers wit...
1 CitationsSource
Conventional intravenous or oral administration of a combination of chemotherapeutics displays poor bioavailability and induces undesirable systemic toxicity. Therefore, localized delivery of such chemotherapeutic combinations using polymeric hydrogels is expected to help in enhancing drug efficacy and reducing systemic toxicity. In this manuscript, we have utilized a chitosan-catechol based hydrogel (CAT-Gel) assembled through catechol-Fe(III) coordinative interactions for localized combination...
10 CitationsSource
#2S. B. GuptaH-Index: 4
Last.Avinash BajajH-Index: 22
view all 6 authors...
Current membrane targeting antimicrobials fail to target mycobacteria due to their hydrophobic membrane structure, ability to form drug-resistant biofilms, and their natural intracellular habitat within the confines of macrophages. In this work, we describe engineering of synthetic antimicrobial polymers (SAMPs) derived from biocompatible polyamides that can target drug-sensitive and drug-resistant mycobacteria with high selectivity. Structure–activity relationship studies revealed that reduced ...
4 CitationsSource
#1Munazza T. FatimaH-Index: 1
#2Abhishek ChanchalH-Index: 1
Last.Aasheesh SrivastavaH-Index: 16
view all 7 authors...
Many hydrophobic drugs encounter severe bioavailability issues owing to their low aqueous solubility and limited cellular uptake. We have designed a series of amphiphilic polyaspartamide polyelectrolytes (PEs) that solubilize such hydrophobic drugs in aqueous medium and enhance their cellular uptake. These PEs were synthesized through controlled (∼20 mol %) derivatization of polysuccinimide (PSI) precursor polymer with hydrophobic amines (of varying alkyl chain lengths, viz. hexyl, octyl, dodecy...
13 CitationsSource
#1S. B. Gupta (Indian Institute of Science Education and Research, Bhopal)H-Index: 4
#2Manish Kumar SinghH-Index: 15
Last.Avinash BajajH-Index: 22
view all 6 authors...
We present the effect of size, charge, and hydrophobicity of anticancer drugs on their drug encapsulation efficacy in an L-alanine-based small-molecule hydrogelator. Entrapment of various anticancer drugs in a hydrogel was depicted and correlated towards interactions between gelator and drug molecules. Hydrogel showed the highest entrapment for 5-fluorouracil, which was as high as ∼1.2 mg mL−1 in 1.5% (w/v) hydrogel; however, with small polar anticancer drugs such as cisplatin and carboplatin, p...
7 CitationsSource