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Per Artursson
Science for Life Laboratory
ChemistryCaco-2BiochemistryAbsorption (pharmacology)Biology
313Publications
77H-index
20.5kCitations
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Publications 318
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#1Irina E. Antonescu (University of Southern Denmark)
#2Maria Karlgren (Uppsala University)H-Index: 7
Last. Carsten Uhd Nielsen (University of Southern Denmark)H-Index: 22
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Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport. In contrast, little is known about the eliminating mechanism clearing acamprosate from the blood in the kidneys, despite the fact that studies have shown renal secretion of acamprosate. The hypothesis of the present study was therefore that renal organic anion transporters (OATs) facilitate the renal excre...
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#1Magnus Ölander (Uppsala University)H-Index: 2
#2Jacek R. Wiśniewski (MPG: Max Planck Society)H-Index: 25
Last. Per Artursson (Science for Life Laboratory)H-Index: 77
view all 3 authors...
BACKGROUND & AIMS: The human liver functions through a complex interplay between parenchymal and non-parenchymal cells. Mass spectrometry-based proteomic analysis of intact tissue has provided an in-depth view of the human liver proteome. However, the predominance of parenchymal cells, i.e. hepatocytes, means that the total tissue proteome mainly reflects hepatocyte expression. Here, we therefore set out to analyze the proteomes of the major parenchymal and non-parenchymal cell types in the huma...
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#1Christine Wegler (AstraZeneca)H-Index: 5
#2Magnus Ölander (Uppsala University)H-Index: 2
Last. Per Artursson (Science for Life Laboratory)H-Index: 77
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Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furth ...
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#1Per Artursson (Uppsala University)H-Index: 77
#2Patrik Lundquist (Uppsala University)H-Index: 8
Negatively charged nanoparticles of about 50 nm in size permit the oral delivery of insulin and other peptide drugs by temporally enhancing the permeability of the intestinal wall.
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#1Veronica Krogstad (Oslo University Hospital)H-Index: 1
#2Alexandra Peric (AstraZeneca)H-Index: 1
Last. Hege Christensen (University of Oslo)H-Index: 20
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The liver and small intestine restrict oral bioavailability of drugs and constitute the main sites of pharmacokinetic drug-drug interactions. Hence, detailed data on hepatic and intestinal activities of drug metabolizing enzymes is important for modelling drug disposition and optimizing pharmacotherapy in different patient populations. The aim of this study was to determine the activities of seven cytochrome P450 (CYP) enzymes in paired liver and small intestinal samples from patients with obesi...
1 CitationsSource
#1Andrea Treyer (Uppsala University)H-Index: 2
#2Sandra Walday (Uppsala University)
Last. Per Artursson (Uppsala University)H-Index: 77
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Purpose The intracellular fraction of unbound compound (fu,cell) is an important parameter for accurate prediction of drug binding to intracellular targets. fu,cell is the result of a passive distribution process of drug molecules partitioning into cellular structures. Initial observations in our laboratory showed an up to 10-fold difference in the fu,cell of a given drug for different cell types. We hypothesized that these differences could be explained by the phospholipid (PL) composition of t...
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#1Bhagwat Prasad (UW: University of Washington)H-Index: 23
#2Brahim Achour (University of Manchester)H-Index: 13
Last. Amin Rostami-Hodjegan (University of Manchester)H-Index: 54
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3 CitationsSource
#1Andrea Treyer (Uppsala University)H-Index: 2
#2Mohammed Ullah (Hoffmann-La Roche)H-Index: 6
Last. Per Artursson (Uppsala University)H-Index: 77
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Accurate prediction of drug-drug interactions (DDI) is a challenging task in drug discovery and development. It requires determination of enzyme inhibition in vitro which is highly system-dependent ...
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#1Magnus Ölander (Uppsala University)H-Index: 2
#2Niklas Handin (Uppsala University)H-Index: 2
Last. Per Artursson (Science for Life Laboratory)H-Index: 77
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Apoptosis is a controlled form of cell death that can be induced by various diseases and exogenous toxicants. Common apoptosis detection methods rely on fluorescent markers, which necessitates the ...
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#1Anne M. Filppula (Uppsala University)H-Index: 1
#2Rezvan Parvizi (Uppsala University)
Last. Per Artursson (Uppsala University)H-Index: 77
view all 5 authors...
The clinical impact of drug-drug interactions based on time-dependent inhibition of cytochrome P450 (CYP) 3A4 has often been overpredicted, likely due to use of improper inhibitor concentration estimates at the enzyme. Here, we investigated if use of cytosolic unbound inhibitor concentrations could improve predictions of time-dependent drug-drug interactions. First, we assessed the inhibitory effects of ten time-dependent CYP3A inhibitors on midazolam 1′-hydroxylation in human liver microsomes. ...
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