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Keith J. Stine
University of Missouri–St. Louis
81Publications
20H-index
1,728Citations
Publications 81
Newest
#1Mithila D. Bandara (UMSL: University of Missouri–St. Louis)H-Index: 2
#2Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
Last.Alexei V. Demchenko (UMSL: University of Missouri–St. Louis)H-Index: 34
view all 3 authors...
Abstract The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has been completed using both linear and convergent strategies. The donor and acceptor protecting and leaving group combinations were found to be of paramount significance to successful couplings.
#1Bishal NepalH-Index: 1
#2Keith J. StineH-Index: 20
The glycoalkaloids which are secondary metabolites from plants have proven to be of significant interest for their biological properties both in terms of their roles in plant biology and the effects they exhibit when ingested by humans. The main feature of the action of glycoalkaloids is their strong binding to 3β-hydroxysterols, such as cholesterol, to form complexes with the consequence that membrane structure is significantly perturbed, and leakage or release of contents inside cells or lipos...
The field of nanomaterials continues to expand with the discovery of new nanostructures opening up new possibilities for both the study of unique physical properties and new applications [...]
#1Salvatore G. Pistorio (UMSL: University of Missouri–St. Louis)H-Index: 4
#2Scott A. Geringer (UMSL: University of Missouri–St. Louis)
Last.Alexei V. Demchenko (UMSL: University of Missouri–St. Louis)H-Index: 34
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Presented herein are two complementary approaches to the synthesis of the core N-glycan pentasaccharide. The first, a traditional manual approach in solution, makes use of the H-bond-mediated aglycone delivery method for the highly diastereoselective introduction of the β-mannosidic linkage at room temperature. The synthesis of the core pentasaccharide was also accomplished using an high-performance liquid chromatography-assisted automated approach. The overall assembly was swift (8 h) and effic...
#1Tinghua Wang (UMSL: University of Missouri–St. Louis)H-Index: 2
#2Yashapal Singh (UMSL: University of Missouri–St. Louis)
Last.Alexei V. Demchenko (UMSL: University of Missouri–St. Louis)H-Index: 3
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#1Matteo Panza (UMSL: University of Missouri–St. Louis)H-Index: 1
#2Salvatore G. Pistorio (UMSL: University of Missouri–St. Louis)H-Index: 4
Last.Alexei V. Demchenko (UMSL: University of Missouri–St. Louis)H-Index: 3
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Advances in carbohydrate chemistry have certainly made common oligosaccharides much more accessible. However, many current methods still rely heavily upon specialized knowledge of carbohydrate chemistry. The application of automated technologies to chemical and life science applications such as genomics and proteomics represents a vibrant field. These automated technologies also present opportunities for their application to organic synthesis, including that of the synthesis of oligosaccharides....
#1Crystal L. O'Neil (UMSL: University of Missouri–St. Louis)H-Index: 1
#2Keith J. Stine (UMSL: University of Missouri–St. Louis)H-Index: 20
Last.Alexei V. Demchenko (UMSL: University of Missouri–St. Louis)H-Index: 3
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#1Jay K. BhattaraiH-Index: 4
#2Dharmendra NeupaneH-Index: 1
Last.Keith J. StineH-Index: 20
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Nanoporous gold (np-Au), because of its high surface area-to-volume ratio, excellent conductivity, chemical inertness, physical stability, biocompatibility, easily tunable pores, and plasmonic properties, has attracted much interested in the field of nanotechnology. It has promising applications in the fields of catalysis, bio/chemical sensing, drug delivery, biomolecules separation and purification, fuel cell development, surface-chemistry-driven actuation, and supercapacitor design. Many chemi...
#1Tinghua Wang (UMSL: University of Missouri–St. Louis)H-Index: 2
#2Swati S. Nigudkar (UMSL: University of Missouri–St. Louis)H-Index: 5
Last.Alexei V. Demchenko (UMSL: University of Missouri–St. Louis)H-Index: 3
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In an attempt to refine a CAN-mediated synthesis of 1,3,4,6-tetra-O-acetyl-α-D-glucopyranose (2-OH glucose) we unexpectedly discovered that this reaction proceeds via the intermediacy of glycosyl nitrates. Improved mechanistic understanding of this reaction led to the development of a more versatile synthesis of 2-OH glucose from a variety of precursors. Also demonstrated is the conversion of 2-OH glucose into a variety of building blocks differentially protected at C-2, a position that is gener...
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