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Chiara Gamberi
Concordia University
19Publications
9H-index
658Citations
Publications 19
Newest
Published on Apr 30, 2019in Journal of Mass Spectrometry2.27
Ethan Yang1
Estimated H-index: 1
(UdeM: Université de Montréal),
Chiara Gamberi9
Estimated H-index: 9
(Concordia University),
Pierre Chaurand15
Estimated H-index: 15
(UdeM: Université de Montréal)
Published on Jan 2, 2019in International Journal of Science Education1.25
Chiara Gamberi9
Estimated H-index: 9
(Concordia University),
Katharine Hall1
Estimated H-index: 1
(Concordia University)
The design and implementation of a scientific writing assignment in a >100 student upper-level undergraduate microbiology class resulted in a peer-reviewed publication in an open-access journal. The primary course objectives and requirements were met by assigning groups of four to five students one of 25 distinct section topics of similar size and complexity that complemented the course materials. Students were taught to identify, read and cite primary scientific literature, to avoid plagiarism,...
Published on Dec 1, 2018
"In the quest for new effective drugs there is the push for faster ways to identify active lead compounds to develop and validate in drug discovery pipelines. Cell culture-based screens are easy to run and can be both standardized and automated to perform efficient high-throughput screens. Combined with the large available compound libraries, they can be useful to identify leads. However, many of such leads have been found to fail in the subsequent validation steps, where system complexity incre...
Published on May 31, 2018in BioMed Research International2.20
Cassandra Millet-Boureima1
Estimated H-index: 1
(Concordia University),
Jessica Porras Marroquin1
Estimated H-index: 1
(Concordia University),
Chiara Gamberi9
Estimated H-index: 9
(Concordia University)
Detoxification is a fundamental function for all living organisms that need to excrete catabolites and toxins to maintain homeostasis. Kidneys are major organs of detoxification that maintain water and electrolyte balance to preserve physiological functions of vertebrates. In insects, the renal function is carried out by Malpighian tubules and nephrocytes. Due to differences in their circulation, the renal systems of mammalians and insects differ in their functional modalities, yet carry out sim...
Published on Jul 17, 2017in Frontiers in Microbiology4.26
Susannah Selber-Hnatiw1
Estimated H-index: 1
(Concordia University),
Belise Rukundo1
Estimated H-index: 1
(Concordia University)
+ 100 AuthorsAlexandra Baird1
Estimated H-index: 1
(Concordia University)
Composed of trillions of individual microbes, the human gut microbiota has adapted to the uniquely diverse environments found in the human intestine. Quickly responding to the variances in the ingested food, the microbiota interacts with the host via reciprocal biochemical signaling to coordinate the exchange of nutrients and proper immune function. Host and microbiota function as a unit which guards its balance against invasion by potential pathogens and which undergoes natural selection. Distu...
Published on Apr 13, 2017in PLOS Genetics5.22
Chiara Gamberi9
Estimated H-index: 9
,
David R. Hipfner5
Estimated H-index: 5
+ 1 AuthorsWilliam D. Lubell1
Estimated H-index: 1
Progressive cystic kidney degeneration underlies diverse renal diseases, including the most common cause of kidney failure, autosomal dominant Polycystic Kidney Disease (PKD). Genetic analyses of patients and animal models have identified several key drivers of this disease. The precise molecular and cellular changes underlying cystogenesis remain, however, elusive. Drosophila mutants lacking the translational regulator Bicaudal C (BicC, the fly ortholog of vertebrate BICC1 implicated in renal c...
Published on Feb 1, 2016in Developmental Biology2.94
Luca Valzania5
Estimated H-index: 5
(UNIBO: University of Bologna),
Hajime Ono12
Estimated H-index: 12
(Kyoto University)
+ 5 AuthorsGiuseppe Gargiulo21
Estimated H-index: 21
(UNIBO: University of Bologna)
Abstract Maternal expression of the translational regulator 4EHP (eIF4E-Homologous Protein) has an established role in generating protein gradients essential for specifying the Drosophila embryonic pattern. We generated a null mutation of 4EHP , which revealed for the first time that it is essential for viability and for completion of development. In fact, 4EHP null larvae, and larvae ubiquitously expressing RNAi targeting 4EHP , are developmentally delayed, fail to grow and eventually die. In a...
Published on Dec 1, 2015
Analysis of Drosophila cuticular structures is a classic genetic tool to infer the efficiency of developmental processes via careful morphological evaluation. When performing genetic screens in pursuit of mutations with developmental effects or during mutational scanning to identify functionally important protein domains, high throughput analyses of cuticles from numerous fly lines becomes necessary. To increase throughput ingenious structures of fly containers have been devised such as fly “con...
Published on Dec 19, 2013in PLOS Genetics5.22
Jordi Solana11
Estimated H-index: 11
(University of Nottingham),
Chiara Gamberi9
Estimated H-index: 9
(McGill University)
+ 5 AuthorsA. Aziz Aboobaker23
Estimated H-index: 23
(University of Oxford)
Post-transcriptional regulatory mechanisms are of fundamental importance to form robust genetic networks, but their roles in stem cell pluripotency remain poorly understood. Here, we use freshwater planarians as a model system to investigate this and uncover a role for CCR4-NOT mediated deadenylation of mRNAs in stem cell differentiation. Planarian adult stem cells, the so-called neoblasts, drive the almost unlimited regenerative capabilities of planarians and allow their ongoing homeostatic tis...
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