Paul Talalay
Johns Hopkins University School of Medicine
Molecular biologyEnzymeChemistryBiochemistryBiology
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Publications 195
#1Hye Youn Cho (NIH: National Institutes of Health)H-Index: 13
#2Laura Miller-DeGraff (NIH: National Institutes of Health)H-Index: 8
Last. Steven R. Kleeberger (NIH: National Institutes of Health)H-Index: 51
view all 13 authors...
Abstract Nrf2 is essential to antioxidant response element (ARE)-mediated host defense. Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets including Nrf2-ARE pathway in chemoprevention. However, the role of SFN in non-malignant airway disorders remain unclear. To test if pre-activation of Nrf2-ARE signaling protects lungs from oxidant-induced acute injury, wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2−/−) mice were given SFN orally or as standardized brocc...
1 CitationsSource
#1Sharadha Dayalan Naidu (Dund.: University of Dundee)H-Index: 10
#2Dina Dikovskaya (Dund.: University of Dundee)H-Index: 10
Last. Albena T. Dinkova-Kostova (Dund.: University of Dundee)H-Index: 55
view all 14 authors...
Autophagy plays a critical role in the maintenance of cellular homeostasis by degrading proteins, lipids and organelles. Autophagy is activated in response to stress, but its regulation in the context of other stress response pathways, such as those mediated by heat shock factor 1 (HSF1) and nuclear factor-erythroid 2 p45-related factor 2 (NRF2), is not well understood. We found that the Michael acceptor bis(2-hydoxybenzylidene)acetone (HBB2), a dual activator of NRF2 and HSF1, protects against ...
12 CitationsSource
#1Y. Aoki (JHUSOM: Johns Hopkins University School of Medicine)
#2S. L. Wehage (JHUSOM: Johns Hopkins University School of Medicine)
Last. Paul Talalay (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 73
view all 3 authors...
BACKGROUND/PURPOSE: Severe alcohol intolerance characterized by flushing, headache, nausea, and tachycardia even after very modest oral alcohol consumption, is common among East Asians (Chinese, Japanese, Koreans) and has been associated with the accumulation of acetaldehyde resulting from genetic polymorphism of aldehyde dehydrogenase (ALDH). These individuals also display erythema of the skin in response to exposure to topical alcohol. We have recently observed that dietary phytochemicals such...
#1Robert A. Wise (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 88
#2Janet Teresa Holbrook (Johns Hopkins University)H-Index: 32
Last. Shyam Biswal (Johns Hopkins University)H-Index: 53
view all 15 authors...
Background COPD patients have high pulmonary and systemic oxidative stress that correlates with severity of disease. Sulforaphane has been shown to induce expression of antioxidant genes via activation of a transcription factor, nuclear factor erythroid-2 related factor 2 (Nrf2). Methods This parallel, placebo-controlled, phase 2, randomized trial was conducted at three US academic medical centers. Patients who met GOLD criteria for COPD and were able to tolerate bronchoscopies were randomly ass...
18 CitationsSource
#1Hua LiuH-Index: 9
#2Paul TalalayH-Index: 73
Last. Jed W. FaheyH-Index: 27
view all 3 authors...
Autism spectrum disorder (ASD) is a complex, life-long neurodevelopmental disorder currently affecting an estimated 1 out of 68 among children aged 8 y in the United States. ASD has complex genetic and epigenetic features that lead to the phenotype and there is no single genetic marker for the diagnosis. Therefore, the diagnosis for ASD is phenotype- based with no validated or credible laboratory tests available. Evidence-based treatments for ASD are limited. There is no FDA approved medical the...
20 CitationsSource
#1Andrea L. Benedict (Johns Hopkins University)H-Index: 6
#2Elena V. Knatko (Dund.: University of Dundee)H-Index: 11
Last. Albena T. Dinkova-KostovaH-Index: 55
view all 11 authors...
#1Elena V. Knatko (Dund.: University of Dundee)H-Index: 11
#2Sally H. Ibbotson (Dund.: University of Dundee)H-Index: 35
Last. Albena T. Dinkova-Kostova (Dund.: University of Dundee)H-Index: 55
view all 17 authors...
The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding proteins with versatile cytoprotective functions. In mice, disruption of Nrf2 increases susceptibility to carcinogens and accelerates disease pathogenesis. Paradoxically, Nrf2 is upregulated in established human tumors, but whether this upregulation drives carcinogenes...
40 CitationsSource
#1Kanwaljit Singh (Harvard University)H-Index: 11
#2Susan L. Connors (Harvard University)H-Index: 20
Last. Andrew W. Zimmerman (Harvard University)H-Index: 34
view all 7 authors...
Abstract Autism spectrum disorder (ASD), characterized by both impaired communication and social interaction, and by stereotypic behavior, affects about 1 in 68, predominantly males. The medico-economic burdens of ASD are enormous, and no recognized treatment targets the core features of ASD. In a placebo-controlled, double-blind, randomized trial, young men (aged 13–27) with moderate to severe ASD received the phytochemical sulforaphane (n = 29)—derived from broccoli sprout extracts—or indistin...
152 CitationsSource
#1Hua Liu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 9
#2Paul Talalay (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 73
Exemestane (6-methyleneandrosta-1,4-diene-3,17-dione) is a synthetic steroidal inhibitor of the aromatase reaction that catalyzes the terminal and rate-limiting step of the biosynthesis of estrogens. It is active clinically in preventing, delaying progression of, and treating mammary cancers, many of which are estrogen receptor-positive. A striking feature of the structure of exemestane is an extended system of conjugated Michael reaction functions, which is also characteristic of inducers of a ...
36 CitationsSource
#1Yusuke Ushida (Kagome)H-Index: 1
#2Paul Talalay (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 73
Aims: Many East Asians are highly intolerant to even modest alcohol consumption. These individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of aldehyde dehydrogenase (ALDH) that metabolizes acetaldehyde to nontoxic acetate. The aim of these studies is to upregulate ALDH by dietary means, thereby reducing acetaldehyde toxicity. Methods: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained...
19 CitationsSource