William R. Markesbery
University of Kentucky
Publications 439
#1Suzanne S. MirraH-Index: 44
#2William R. MarkesberyH-Index: 111
#1Roy A. PatchellH-Index: 34
#2Phillip A. TibbsH-Index: 29
Last.Byron YoungH-Index: 39
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A secure servicing system for an automatic teller machine (ATM) or similar machine. An ATM is mounted on a rotatable/translatable baseplate in a kiosk with the operating side flush with an opening in the kiosk. By rotating and translating the baseplate, the ATM operating side is moved to a secure space inside the kiosk, providing access through a kiosk door for service. A blank side at least partially fills the opening. The baseplate is mounted on rollers and rotated by a driven bar connected be...
124 Citations
#1Diego IaconoH-Index: 8
#2Peter P. Zandi (Johns Hopkins University)H-Index: 65
Last.Juan C. Troncoso (Johns Hopkins University)H-Index: 81
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Asymptomatic Alzheimer’s disease (ASYMAD) subjects are individuals characterized by preserved cognition before death despite substantial AD pathology at autopsy. ASYMAD subjects show comparable levels of AD pathology, i.e. β-amyloid neuritic plaques (Aβ-NP) and tau-neurofibrillary tangles (NFT), to those observed in mild cognitive impairment (MCI) and some definite AD cases. Previous clinicopathologic studies on ASYMAD subjects have shown specific phenomena of hypertrophy in the cell bodies, nuc...
5 CitationsSource
#1James A. MortimerH-Index: 52
#2David A. SnowdonH-Index: 37
Last.William R. MarkesberyH-Index: 111
view all 3 authors...
3 CitationsSource
#1A-Ryeong Gwon (SKKU: Sungkyunkwan University)H-Index: 11
#2Jong-Sung Park (SKKU: Sungkyunkwan University)H-Index: 18
Last.Dong-Gyu Jo (SKKU: Sungkyunkwan University)H-Index: 37
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The cause of elevated level of amyloid β-peptide (Aβ42) in common late-onset sporadic (AD) has not been established. Here we show that the membrane lipid peroxidation product 4-hydroxynonenal (HNE) is associated with amyloid and neurodegenerative pathologies in AD, and that it enhances γ-secretase activity and Aβ42 production in neurons. The γ-secretase substrate receptor, nicastrin was found to be modified by HNE in cultured neurons and in brain specimens from AD patients, in which HNE-nicastri...
45 CitationsSource
#1Melissa A. Bradley (UK: University of Kentucky)H-Index: 6
#2Shuling Xiong-Fister (UK: University of Kentucky)H-Index: 1
Last.Mark A. Lovell (UK: University of Kentucky)H-Index: 63
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Abstract Multiple studies have demonstrated elevations of α, β-unsaturated aldehydes including 4-hydroxynonenal (HNE) and acrolein, in vulnerable regions of mild cognitive impairment (MCI), preclinical Alzheimer's disease (PCAD), and late stage Alzheimer's disease (LAD) brain. However, there has been limited study of a third member, 4-hydroxyhexenal (HHE), a diffusible lipid peroxidation product of the ω-3 polyunstataturated fatty acids (PUFAs). In the present study levels of extractable and pro...
54 CitationsSource
#1Leonard W. Poon (UGA: University of Georgia)H-Index: 41
#2John L. Woodard (WSU: Wayne State University)H-Index: 25
Last.William R. Markesbery (UK: University of Kentucky)H-Index: 111
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The goals of this article are to (a) establish the concurrent and clinical validity of the Global Deterioration scale in assessing cognitive functions and stages of dementia among centenarians, (b) identify the prevalence of all-cause dementia in representative samples of centenarians, and (c) demonstrate how variations in sample demographic characteristics could significantly affect estimates of dementia prevalence. A quarter of the 244 centenarians in a population-based sample had no objective...
40 CitationsSource
#1Qunxing Ding (KSU: Kent State University)H-Index: 1
#2Haiyan Zhu (KSU: Kent State University)H-Index: 1
Last.William R. Markesbery (UK: University of Kentucky)H-Index: 111
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8 CitationsSource
#1Marc Gleichmann (NIH: National Institutes of Health)H-Index: 15
#2Yongqing Zhang (NIH: National Institutes of Health)H-Index: 36
Last.Mark P. Mattson (NIH: National Institutes of Health)H-Index: 179
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Abstract Activity-dependent modulation of neuronal gene expression promotes neuronal survival and plasticity, and neuronal network activity is perturbed in aging and Alzheimer's disease (AD). Here we show that cerebral cortical neurons respond to chronic suppression of excitability by downregulating the expression of genes and their encoded proteins involved in inhibitory transmission (GABAergic and somatostatin) and Ca 2+ signaling; alterations in pathways involved in lipid metabolism and energ...
31 CitationsSource
#1Patricia L. Kramer (OHSU: Oregon Health & Science University)H-Index: 51
#2Haiyan Xu (Rockefeller University)H-Index: 1
Last.Jurg Ott (CAS: Chinese Academy of Sciences)H-Index: 88
view all 17 authors...
Many elderly individuals remain dementia-free throughout their life. However, some of these individuals exhibit Alzheimer disease neuropathology on autopsy, evidenced by neurofibrillary tangles (NFTs) in AD-specific brain regions. We conducted a genome-wide association study to identify genetic mechanisms that distinguish non-demented elderly with a heavy NFT burden from those with a low NFT burden. The study included 299 non-demented subjects with autopsy (185 subjects with low and 114 with hig...
75 CitationsSource