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FanJin
80Publications
47H-index
6,703Citations
Publications 80
Newest
#1Ping-Ping Bao (CDC: Centers for Disease Control and Prevention)H-Index: 10
#2Ying Zheng (CDC: Centers for Disease Control and Prevention)H-Index: 40
Last.Fan Wu (CDC: Centers for Disease Control and Prevention)H-Index: 3
view all 10 authors...
Background To provide a comprehensive overview of temporal trends in cancer incidence during 1973–2010 in urban Shanghai.
#1Zhezhou Huang (CDC: Centers for Disease Control and Prevention)H-Index: 5
#2Alicia Beeghly-Fadiel (Vandy: Vanderbilt University)H-Index: 17
Last.Wei Lu (CDC: Centers for Disease Control and Prevention)H-Index: 49
view all 13 authors...
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Socioeconomic development and urbanization have resulted in dramatic changes in cancer incidence and mortality in China. As one of the largest and most developed cities in China, Shanghai's cancer rates reflect the changing burden of cancer in China. This study was undertaken to evaluate trends and quantify changes in the incidence and mortality of breast, ovarian, endometrial, and cervical cancers among female residents of ur...
#1Alecia M. Fair (Meharry Medical College)H-Index: 13
#2Qi Dai (Vandy: Vanderbilt University)H-Index: 51
Last.Wei Zheng (Vandy: Vanderbilt University)H-Index: 73
view all 8 authors...
Abstract Background : American women are five times more likely to be at risk for breast cancer than women from Asian countries. Epidemiologic studies have linked energy balance to an increased risk of breast cancer, yet few studies have investigated potential mediators of this association with Chinese women. We examined the above association by blood levels of insulin-like growth factors (IGFs), binding proteins, and C-peptide in the Shanghai Breast Cancer Study (SBCS), a case–control study con...
#1Jirong Long (Vandy: Vanderbilt University)H-Index: 51
#2Xiao-Ou Shu (Vandy: Vanderbilt University)H-Index: 100
Last.Wei Zheng (Vandy: Vanderbilt University)H-Index: 105
view all 7 authors...
Abstract The Cytochrome P450 1B1 ( CYP1B1 ) is one of the major CYP450 enzymes catalyzing 4-hydroxylation, an important elimination step for estrogens. Relatively little is known, however, about the impact of this gene on the onset and cessation of menstruation, which are the significant milestones in a woman's life and predictors of many hormone related diseases. In this report, we described the association of four SNPs in the CYP1B1 gene, Arg48Gly, Ala119Ser, Leu432Val, and Asp449Asp, with the...
Vascular endothelial growth factor (VEGF) is a major angiogenic factor involved in a number of pathologic processes, including neovascularization, a crucial step in the development of solid malignancies. Using data and specimens collected in the Shanghai Breast Cancer Study, a population-based case-control study conducted in urban Shanghai, China from 1996 to 1998, we evaluated the association of VEGF gene polymorphisms with breast cancer risk. Included in this study were 1,093 cases and 1,184 a...
Methionine, the precursor for the universal methyl donor, S -adenosylmethionine, is produced through the irreversible transfer of a methyl group from 5-methyltetrahydrofolate. This reaction is regulated by two enzymes, methionine synthase ( MTR ) and methionine synthase reductase ( MTRR ). MTR is
#1Wei Zheng (Vandy: Vanderbilt University)H-Index: 105
#2Wong Ho ChowH-Index: 78
Last.Ying GaoH-Index: 96
view all 12 authors...
Although cancer is a major cause of morbidity and mortality in most nations, the spectrum of cancer occurrence varies substantially worldwide. Most previous epidemiologic studies investigating cancer etiology were conducted in North American and western European countries that are relatively homogenous in terms of cancer spectrums and many lifestyle exposures. These limitations may have hindered these studies from evaluating some important etiologic hypotheses. From 1996 to 2000, the Shanghai Wo...
We evaluated the hypothesis that a pattern of behavioral exposures indicating positive energy balance [i.e., less exercise/sport activity, high body mass index (BMI), or high energy intake] would be associated with an increased breast cancer risk in the Shanghai Breast Cancer Study, a population-based study of 1,459 incident breast cancer cases and 1,556 age frequency-matched controls. Participants completed in-person interviews that collected information on breast cancer risk factors, usual die...
#1Yong CuiH-Index: 15
#2Xiao-Ou ShuH-Index: 100
Last.Wei ZhengH-Index: 105
view all 8 authors...
Sex hormones play a central role in the development of breast cancer. Sex hormone–binding globulin (SHBG) modulates the bioavailability of circulating sex hormones and regulates their signaling system in the breast tissue. We evaluated the association of a common functional polymorphism ( Asp327Asn ) in the SHBG gene with breast cancer risk in a population-based case-control study (1,106 cases and 1,180 controls) conducted in Shanghai, China. The variant Asn allele was associated with a reduced ...
#1Gong Yang (VUMC: Vanderbilt University Medical Center)H-Index: 54
#2Xiao-Ou Shu (VUMC: Vanderbilt University Medical Center)H-Index: 100
Last.Wei Zheng (VUMC: Vanderbilt University Medical Center)H-Index: 105
view all 8 authors...
Background: Several small-scale clinical trials have suggested a potential beneficial effect of short-term soy consumption on blood pressure (BP). Data are scanty on long-term effects of the usual intake of soy foods on BP in general populations. Objective: Our aim was to examine the association between usual intake of soy foods and BP. Design: The usual intake of soy foods was assessed at baseline, and BP was measured 2–3 y after the baseline survey among 45 694 participants of the Shanghai Wom...
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