CancerSurgeryHepatocellular carcinomaGeneral surgeryMedicine
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Publications 432
#1Albert C. Y. ChanH-Index: 26
Last. Chung Mau LoH-Index: 81
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OBJECTIVE: The aim of this study was to evaluate the short- and long-term outcome of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for hepatitis-related hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: ALPPS has been advocated for future liver remnant (FLR) augmentation in liver metastasis or noncirrhotic liver tumors in recent years. Data on the effect of ALPPS in chronic hepatitis or cirrhosis-related HCC remained scarce. METHODS: Data for clinicop...
2 CitationsSource
#1Ian ChauH-Index: 47
Last. Andrew X Zhu A XH-Index: 66
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#1Ian ChauH-Index: 47
#2Markus Peck-Radosavljevic (Medical University of Vienna)H-Index: 52
Last. Andrew X Zhu A X (Harvard University)H-Index: 66
view all 21 authors...
1 CitationsSource
#1Ian Chau (The Royal Marsden NHS Foundation Trust)H-Index: 47
#2Joon Oh Park (SKKU: Sungkyunkwan University)H-Index: 51
Last. Andrew X Zhu A X (Harvard University)H-Index: 66
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Post-hoc analyses of AFP response and progression and their relationship with objective measures of response and survival were performed in patients from REACH. Serum AFP was measured at baseline and every 3 cycles (2 weeks/cycle). Associations between AFP and radiographic progression and efficacy end points were analysed. Median percent AFP increase from baseline was smaller in the ramucirumab than in the placebo arm throughout treatment. Time to AFP progression (HR 0.621; P < 0.0001) and to ra...
4 CitationsSource
#1Won Young Tak (KNU: Kyungpook National University)H-Index: 34
#2Shi Ming Lin (CGU: Chang Gung University)H-Index: 3
Last. Riccardo Lencioni (UM: University of Miami)H-Index: 62
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Purpose: Lyso-thermosensitive liposomal doxorubicin (LTLD) consists of doxorubicin contained within a heat-sensitive liposome. When heated to >=40oC, LTLD locally releases a high concentration of doxorubicin. We aimed to determine whether adding LTLD improves the efficacy of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) lesions with a maximum diameter (dmax) of 3 to 7 cm. Patients and Methods: The HEAT Study was a randomized, double-blind, dummy-controlled trial of RFA +/- LTL...
18 CitationsSource
#1Felix H. Shek (ZJU: Zhejiang University)H-Index: 7
#2Ruibang Luo (HKU: University of Hong Kong)H-Index: 25
Last. Nikki P. Lee (ZJU: Zhejiang University)H-Index: 30
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Background Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. Previously, we reported that cadherin-17 (CDH17) and its related CDH17/β-catenin axis may be responsible for inducing HCC in a subset of patients exhibiting CDH17 over-expression. Here we aimed at obtaining a better understanding of the CDH17-related HCC biology and to obtain further indications for the design of targeted therapies in CDH17 over-expressing HCC patients.
3 CitationsSource
#1Wei-Chu Chie (NTU: National Taiwan University)H-Index: 31
#2Jane M Blazeby (UoB: University of Bristol)H-Index: 58
Last. Valérie Vilgrain (Paris Diderot University)H-Index: 72
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Aim The aim of this study is to explore the possible effects of clinical and cultural characteristics of hepatocellular carcinoma on patients’ health-related quality of life (HRQoL). Methods Patients with hepatocellular carcinoma from Asian and European countries completed the EORTC QLQ-C30 and the EORTC QLQ-HCC18. Comparisons were made using Student's t-test and Wilcoxon rank-sum test with method of false discovery to correct multiple comparisons. Multiway analysis of variance and model selecti...
4 CitationsSource
#1Daniel W. H. Ho (HKU: University of Hong Kong)H-Index: 13
#2Lo K. Chan (HKU: University of Hong Kong)H-Index: 1
Last. Irene Oi-Lin Ng (HKU: University of Hong Kong)H-Index: 72
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Objective We investigated the mutational landscape of mammalian target of rapamycin (mTOR) signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV background, aiming to evaluate and delineate mutation-dependent mechanism of mTOR hyperactivation in hepatocarcinogenesis. Design We performed next-generation sequencing on human HCC samples and cell line panel. Systematic mutational screening of mTOR pathway-related genes was undertaken and mutant genes were evaluated based on their r...
23 CitationsSource
#1Ian Chau (The Royal Marsden NHS Foundation Trust)H-Index: 47
Last. Andrew X Zhu A X (Harvard University)H-Index: 66
view all 21 authors...
Abstract Purpose To report patient-focused outcomes as measured by quality of life (QoL) and performance status (PS) in REACH, a phase III placebo-controlled randomised study, assessing ramucirumab in advanced hepatocellular carcinoma (HCC) patients who received prior sorafenib. Methods Eligible patients had advanced HCC, Child-Pugh A, PS 0 or 1 and prior sorafenib. Patients received ramucirumab (8 mg/kg) or placebo (1:1) on day 1 of a 2-week cycle. QoL was assessed by FACT Hepatobiliary Symptom...
14 CitationsSource
#2Lo Kong ChanH-Index: 5
Last. Irene Oi-Lin NgH-Index: 72
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