Peter G. Vekilov
University of Houston
ChemistryCrystallizationCrystal growthNucleationCrystallography
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Publications 219
#1Peter G. Vekilov (UH: University of Houston)H-Index: 47
#2David S Yang (UH: University of Houston)H-Index: 1
Last. Anatoly B. Kolomeisky (Rice University)H-Index: 37
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The oncogenic properties of mutant p53 have been ascribed to destabilization of the p53 conformation, followed by aggregation into insoluble fibrils. Here we combine immunofluorescent 3D confocal microscopy of breast cancer cells expressing the p53 mutant Arg248Gln (R248Q) with light scattering from solutions of the purified protein and molecular simulations to probe the mechanisms that govern phase behaviors of the mutant across multiple length scales, from cellular to molecular. We establish t...
1 CitationsSource
#1Wenchuan Ma (UH: University of Houston)H-Index: 1
#2James F. Lutsko (ULB: Université libre de Bruxelles)H-Index: 26
Last. Peter G. Vekilov (UH: University of Houston)H-Index: 47
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Ubiquitous processes in nature and the industry exploit crystallization from multicomponent environments1–5; however, laboratory efforts have focused on the crystallization of pure solutes6,7 and the effects of single growth modifiers8,9. Here we examine the molecular mechanisms employed by pairs of inhibitors in blocking the crystallization of haematin, which is a model organic compound with relevance to the physiology of malaria parasites10,11. We use a combination of scanning probe microscopy...
1 CitationsSource
#1Lu Lu (Brown University)H-Index: 5
#2Zhen Li (Brown University)H-Index: 23
Last. George Em Karniadakis (Brown University)H-Index: 76
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Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics under organ-specific conditions, which are difficult to assess with existing experimental techniques. Thus, we developed a kinetic model based on the classical nucleation theory to examine the effective...
2 CitationsSource
#1Monika Warzecha (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 6
#2Lakshmanji Verma (UH: University of Houston)
Last. Peter G. Vekilov (UH: University of Houston)H-Index: 47
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#1Peter G. VekilovH-Index: 47
#1Yuechuan Xu (UH: University of Houston)H-Index: 1
#2Mohammad S. Safari (UH: University of Houston)H-Index: 4
Last. Peter G. Vekilov (UH: University of Houston)H-Index: 47
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Oligomers and fibrils of the amyloid-β (Aβ) peptide are implicated in the pathology of Alzheimer’s disease. Here, we monitor the growth of individual Aβ40 fibrils by time-resolved in situ atomic force microscopy and thereby directly measure fibril growth rates. The measured growth rates in a population of fibrils that includes both single protofilaments and bundles of filaments are independent of the fibril thickness, indicating that cooperation between adjacent protofilaments does not affect in...
1 CitationsSource
Atoms of a metal alloy have been tracked as they form crystal nuclei — the first ordered clusters of atoms or molecules produced during crystallization. The findings might help to develop a general nucleation theory. Observations of crystal nucleation.
1 CitationsSource
#1Mohammad S. Safari (Princeton University)H-Index: 4
#2Zhiqing Wang (UH: University of Houston)H-Index: 1
Last. Peter G. Vekilov (UH: University of Houston)H-Index: 47
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Summary About half of human cancers are associated with mutations of the tumor suppressor p53. Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-type and mutant p53. The thermodynamic and kinetic mechanisms of p53 aggregation are poorly understood. Here we find that wild-type p53 forms an anomalous liquid phase. The liquid condensates exhibit several behaviors beyond the scope of classical phase transition theories: their size, ca. 100 nm, is independen...
4 CitationsSource
#1Katy N. Olafson (UH: University of Houston)H-Index: 8
#2R. John Clark (UH: University of Houston)H-Index: 1
Last. Jeffrey D. Rimer (UH: University of Houston)H-Index: 24
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A critical aspect of material synthesis is solvent structuring at solid–liquid interfaces, which can impact the adsorption of solute and growth modifiers on an underlying substrate. In general, the impact of solvent structuring on molecular sorbate interactions with solid sorbents is poorly understood. This is particularly true for processes that occur in organic media, such as hematin crystallization, which is crucial to the survival of malaria parasites. Here, we use chemical force microscopy ...