Peter G. Vekilov
University of Houston
Publications 220
#1Lu Lu (Brown University)H-Index: 4
#2Zhen Li (Brown University)H-Index: 22
Last.George Em Karniadakis (Brown University)H-Index: 72
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Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of deoxy-HbS and erythrocyte sickling. Development of anti-sickling therapies requires quantitative understanding of HbS polymerization kinetics under organ-specific conditions, which are difficult to assess with existing experimental techniques. Thus, we developed a kinetic model based on the classical nucleation theory to examine the effective...
#1Monika Warzecha (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 5
#2Lakshmanji Verma (UH: University of Houston)
Last.Peter G. Vekilov (UH: University of Houston)H-Index: 47
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Oligomers and fibrils of the amyloid-β (Aβ) peptide are implicated in the pathology of Alzheimer’s disease. Here, we monitor the growth of individual Aβ40 fibrils by time-resolved in situ atomic force microscopy and thereby directly measure fibril growth rates. The measured growth rates in a population of fibrils that includes both single protofilaments and bundles of filaments are independent of the fibril thickness, indicating that cooperation between adjacent protofilaments does not affect in...
Atoms of a metal alloy have been tracked as they form crystal nuclei — the first ordered clusters of atoms or molecules produced during crystallization. The findings might help to develop a general nucleation theory. Observations of crystal nucleation.
#1Mohammad S. Safari (Princeton University)H-Index: 3
#2Zhiqing Wang (UH: University of Houston)H-Index: 1
Last.Peter G. Vekilov (UH: University of Houston)H-Index: 47
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Summary About half of human cancers are associated with mutations of the tumor suppressor p53. Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-type and mutant p53. The thermodynamic and kinetic mechanisms of p53 aggregation are poorly understood. Here we find that wild-type p53 forms an anomalous liquid phase. The liquid condensates exhibit several behaviors beyond the scope of classical phase transition theories: their size, ca. 100 nm, is independen...
#1Katy N. Olafson (UH: University of Houston)H-Index: 8
#2R. John Clark (UH: University of Houston)H-Index: 1
Last.Jeffrey D. Rimer (UH: University of Houston)H-Index: 23
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A critical aspect of material synthesis is solvent structuring at solid–liquid interfaces, which can impact the adsorption of solute and growth modifiers on an underlying substrate. In general, the impact of solvent structuring on molecular sorbate interactions with solid sorbents is poorly understood. This is particularly true for processes that occur in organic media, such as hematin crystallization, which is crucial to the survival of malaria parasites. Here, we use chemical force microscopy ...
#1Peter G. Vekilov (UH: University of Houston)H-Index: 47
#2Jacob W. McCabe (A&M: Texas A&M University)H-Index: 2
Last.Jacinta C. Conrad (UH: University of Houston)H-Index: 18
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Protein crystallization is central to understanding of molecular structure in biology, a vital part of processes in the pharmaceutical industry, and a crucial component of numerous disease pathologies. Crystallization starts with nucleation and how nucleation proceeds determines the crystallization rate and essential properties of the resulting crystal population. Recent results with several proteins indicate that crystals nucleate within preformed mesoscopic protein-rich clusters. The origin of...
#1Monika Warzecha (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 5
#2Mohammad S. Safari (UH: University of Houston)H-Index: 3
Last.Peter G. Vekilov (UH: University of Houston)H-Index: 47
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An organic molecule may crystallize in numerous distinct lattices, and the slow and unpredictable transitions between multiple crystal forms are a significant concern in its pharmaceutical application. Recent results indicate that the transformation of olanzapine (OZPN) from anhydrous to hydrate crystals is mediated by mesoscopic solute-rich clusters. Here we demonstrate the existence of such clusters in undersaturated OZPN solutions in purely aqueous and mixed EtOH/aqueous solvents. The cluster...