John VanSwieten
Publications 413
#1Willem S. Eikelboom (EUR: Erasmus University Rotterdam)H-Index: 1
#2Ellen Singleton (UvA: University of Amsterdam)
Last.Janne M. Papma (EUR: Erasmus University Rotterdam)H-Index: 9
view all 21 authors...
Background: Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and are associated with various disadvantageous clinical outcomes including a negative impact on quality of life, caregiver burden, and accelerated disease progression. Despite growing evidence of the efficacy of (non)pharmacological interventions to reduce these symptoms, NPS remain underrecognized and undertreated in memory clinics. The BEhavioural ...
#1Frederike W. Riemslagh (Erasmus University Medical Center)H-Index: 1
#2Hannes Lans (Erasmus University Medical Center)H-Index: 18
Last.Rob Willemsen (Erasmus University Medical Center)H-Index: 61
view all 10 authors...
Human homologue of yeast UV excision repair protein Rad23b (HR23B) inclusions are found in a number of neurodegenerative diseases, including frontotemporal dementia (FTD), Huntington’s disease (HD), spinocerebellar ataxia type 3 and 7 (SCA3/7), fragile X associated tremor/ataxia syndrome (FXTAS) and Parkinson’s disease (PD). Here, we describe HR23B pathology in C9ORF72 linked FTD and amyotrophic lateral sclerosis (ALS) cases. HR23B presented in neuropils, intranuclear inclusions and cytoplasmic ...
#1Ruben Smith (Lund University)H-Index: 20
#2Alexander Frizell Santillo (Lund University)H-Index: 11
Last.Oskar Hansson (Lund University)H-Index: 64
view all 10 authors...
Retention of 18F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if 18F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent 18F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used f...
Background Multimodal MRI-based classification may aid early frontotemporal dementia (FTD) diagnosis. Recently, presymptomatic FTD mutation carriers, who have a high risk of developing FTD, were separated beyond chance level from controls using MRI-based classification. However, it is currently unknown how these scores from classification models progress as mutation carriers approach symptom onset. In this longitudinal study, we investigated multimodal MRI-based classification scores between pre...
#1Tamara P. TavaresH-Index: 4
Last.Elizabeth FingerH-Index: 25
view all 23 authors...
Objective To characterize the time course of ventricular volume expansion in genetic frontotemporal dementia (FTD) and identify the onset time and rates of ventricular expansion in presymptomatic FTD mutation carriers. Methods Participants included patients with a mutation in MAPT, PGRN, or C9orf72, or first-degree relatives of mutation carriers from the GENFI study with MRI scans at study baseline and at 1 year follow-up. Ventricular volumes were obtained from MRI scans using FreeSurfer, with m...
1 CitationsSource
#1Stefano Gazzina (University of Brescia)H-Index: 10
#2Mario Grassi (UNIPV: University of Pavia)H-Index: 30
Last.Barbara Borroni (University of Brescia)H-Index: 48
view all 33 authors...
Objective Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods Two-hundred twent...
#1Rozanna MeijboomH-Index: 6
#2Rebecca M. E. Steketee (EUR: Erasmus University Rotterdam)H-Index: 7
Last.Marion Smits (EUR: Erasmus University Rotterdam)H-Index: 33
view all 8 authors...
Objectives This study explored group-wise quantitative measures of tract-specific white matter (WM) microstructure and functional default mode network (DMN) connectivity to establish an initial indication of their clinical applicability for early-stage and follow-up differential diagnosis of Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD).
#1Gesine Respondek (TUM: Technische Universität München)H-Index: 12
#2Max‐Joseph Grimm (TUM: Technische Universität München)H-Index: 1
Last.Günter U. Höglinger (TUM: Technische Universität München)H-Index: 40
view all 19 authors...
#1Lieke H.H. Meeter (EUR: Erasmus University Rotterdam)H-Index: 8
#2Rebecca M. E. Steketee (EUR: Erasmus University Rotterdam)H-Index: 7
Last.John VanSwieten (EUR: Erasmus University Rotterdam)H-Index: 71
view all 47 authors...
Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we inves...
1 CitationsSource
#1Claire Bridel (VU: VU University Amsterdam)H-Index: 5
#2Wessel N. van Wieringen (VU: VU University Amsterdam)H-Index: 22
Last.Edward J. Wild (UCL Institute of Neurology)H-Index: 27
view all 77 authors...
textabstractImportance: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date. Objectives: To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating...
5 CitationsSource