Holger J. Schünemann
McMaster University
Randomized controlled trialPhysical therapyEvidence-based medicineGuidelineMedicine
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Publications 745
#1Thomas Piggott (McMaster University)H-Index: 1
#2Rebecca L. Morgan (McMaster University)H-Index: 14
Last. Holger J. Schünemann (McMaster University)H-Index: 109
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Abstract Objective The GRADE system for assessing certainty in a body of evidence currently uses two-levels, serious and very serious, for downgrading on a single domain. In the context of newer risk of bias instruments, such as ROBINS-I, evidence generated by non-randomised studies may justify rating down by more than 2 levels on a single domain. Given the importance users of GRADE assign to terminology, our objective was to assess what term GRADE stakeholders would prefer for rating down certa...
#1Jean BousquetH-Index: 128
#2John FarrellH-Index: 22
Last. J. M. AntoH-Index: 25
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#1Itziar Etxeandia-Ikobaltzeta (McMaster University)H-Index: 9
#2Yuan Zhang (McMaster University)H-Index: 32
Last. Ru Chen (Peking Union Medical College)
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Values and preferences relate to the importance that patients place on health outcomes (eg, bleeding, having a deep venous thrombosis) and are essential when weighing benefits and harms in guideline recommendations. To inform the American Society of Hematology guidelines for management of venous thromboembolism (VTE) disease, we conducted a systematic review of patients' values and preferences related to VTE. We searched Medline, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, ...
#1Nancy Santesso (McMaster University)H-Index: 31
#2Claire Glenton (FHI: Norwegian Institute of Public Health)H-Index: 28
Last. Holger J. Schünemann (McMaster University)H-Index: 109
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Abstract Objectives Clear communication of systematic review findings will help readers and decision makers. We built on previous work to develop an approach that improves the clarity of statements to convey findings and that draws on Grading of Recommendations Assessment, Development and Evaluation (GRADE). Study Design and Setting We conducted workshops including 80 attendants and a survey of 110 producers and users of systematic reviews. We calculated acceptability of statements and revised t...
4 CitationsSource
#1Dennis Falzon (WHO: World Health Organization)H-Index: 30
#2Holger J. Schünemann (McMaster University)H-Index: 109
Last. Tereza Kasaeva (WHO: World Health Organization)H-Index: 1
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WHO MDR-TB treatment guidelines detail how evidence and other considerations are used to develop recommendations
#1Andrea Darzi (McMaster University)H-Index: 7
#2Samer G. Karam (McMaster University)
Last. Michael B. Streiff (Johns Hopkins University)H-Index: 43
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#1Nancy Santesso (McMaster University)H-Index: 31
#2Angela M. Barbara (McMaster University)H-Index: 8
Last. Holger J. Schünemann (McMaster University)H-Index: 109
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Abstract Objectives Surveys can inform important health care questions. However, should decision makers believe strong conclusions that authors of surveys report? Objectives of this systematic survey of surveys are to describe the characteristics and conduct of surveys and investigate the association of the conduct with the conclusions. Study design and setting We randomly selected 180 surveys published over one year in core clinical journals that included a self-report instrument to elicit know...
#1Holger J. SchünemannH-Index: 109
#2Reem A. MustafaH-Index: 30
Last. Stefan LangeH-Index: 22
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Abstract Objectives This article provides updated GRADE guidance about how authors of systematic reviews and health technology assessments (HTA) and guideline developers can assess the results and the certainty of evidence (also known as quality of the evidence or confidence in the estimates) of a body of evidence addressing test accuracy (TA). Study Design and Setting We present an overview of the GRADE approach and guidance for rating certainty in TA in clinical and public health and review th...
#1Rasha KhatibH-Index: 19
#2Stephanie Ross (McMaster University)H-Index: 16
Last. Veena Manja (UC Davis: University of California, Davis)H-Index: 11
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