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Stephanie Downs-Canner
University of Pittsburgh
14Publications
8H-index
183Citations
Publications 14
Newest
#1Vernissia TamH-Index: 5
#2Mazen S. ZenatiH-Index: 27
view all 10 authors...
Context Infected pancreatic necrosis is traditionally approached with open necrosectomy. The 2010 randomized controlled PANTER trial proposed a “Step-Up” approach with fewer major complications, comparable mortality, and fewer operations. Objective We sought to evaluate the practical adherence to the Step-Up approach at a tertiary care institution. Design Retrospective, observational study comparing outcomes between patients treated in the “early” pre-PANTER trial period (2006-2010) and “late” p...
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Yongli Shuai (University of Pittsburgh)H-Index: 20
Last.Haroon A. Choudry (University of Pittsburgh)H-Index: 15
view all 8 authors...
Abstract Background To determine if a select subgroup of patients with combined liver and peritoneal colorectal metastases would derive oncologic benefit from surgical resection as a component of multimodality treatment. Materials and methods We retrospectively compared 32 patients with combined colorectal peritoneal and liver metastases (CRLM) and 173 patients with peritoneal metastases only (CRPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC). Ka...
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Sara E. Berkey (University of Pittsburgh)H-Index: 3
Last.Nataša Obermajer (University of Pittsburgh)H-Index: 26
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Th17 cells can transdifferentiate into regulatory T (Treg) cells. Here the authors characterize tumour-driven Th17-to-Treg cell transdifferentiation and identify potential cancer therapy targets.
#1Casey Ager (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Matthew J. Reilley (University of Texas MD Anderson Cancer Center)H-Index: 4
Last.Rebecca S. ReevesH-Index: 1
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About this supplement These abstracts have been published as part of Journal for ImmunoTherapy of Cancer Volume 4 Suppl 1, 2016. The full contents of the supplement are available online at http://jitc.biomedcentral.com/articles/supplements/volume-4-supplement-1. Please note that this is part 1 of 2.
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Zong Sheng Guo (University of Pittsburgh)H-Index: 9
Last.Herbert J. Zeh (University of Pittsburgh)H-Index: 60
view all 11 authors...
We have conducted a phase 1 study of intravenous vvDD, a Western Reserve strain oncolytic vaccinia virus, on 11 patients with standard treatment-refractory advanced colorectal or other solid cancers. The primary endpoints were maximum tolerated dose and associated toxicity while secondary endpoints were pharmacokinetics, pharmacodynamics, immune responses, and antitumor activity. No dose-limiting toxicities and treatment related severe adverse events were observed. The most common adverse events...
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Deepa Magge (University of Pittsburgh)H-Index: 8
Last.David L. Bartlett (University of Pittsburgh)H-Index: 48
view all 9 authors...
Background Complement is a central part of both the innate and adaptive immune response and its activation has traditionally been considered part of the immunosurveillance response against cancer. Its pro-inflammatory role and its contribution to the development of many illnesses associated with inflammatory states implicate complement in carcinogenesis.
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Mazen S. Zenati (University of Pittsburgh)H-Index: 27
Last.Kenneth K.W. Lee (University of Pittsburgh)H-Index: 21
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Background and Objectives The natural history of pulmonary metastases from pancreatic ductal adenocarcinoma (PDAC) is not well studied. Limited evidence suggests patients with isolated pulmonary metastases from PDAC follow a more benign clinical course than those with other sites of metastases.
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Ying Ding (University of Pittsburgh)H-Index: 12
Last.Herbert J. Zeh (University of Pittsburgh)H-Index: 60
view all 12 authors...
Background Postoperative pancreatic fistulas (POPFs) are potentially morbid complications that often require therapeutic interventions. Distal pancreatectomy performed during cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) puts patients at risk for POPF. The authors hypothesized that POPFs are more severe after CRS/HIPEC than after pancreatectomy alone.
#1Stephanie Downs-Canner (University of Pittsburgh)H-Index: 8
#2Wald J. Van der Vliet (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
Last.Herbert J. Zeh (University of Pittsburgh)H-Index: 60
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Introduction Benign duodenal and periampullary tumors are uncommon lesions requiring careful attention to their complex anatomic relationships with the major and minor papillae as well as the gastric outlet during surgical intervention. While endoscopy is less morbid than open resection, many lesions are not amenable to endoscopic removal. Robotic surgery offers technical advantages above traditional laparoscopy, and we demonstrate the safety and feasibility of this approach for a variety of duo...
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