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Jan K. Buitelaar
Radboud University Nijmegen
PsychiatryDevelopmental psychologyPsychologyAttention deficit hyperactivity disorderClinical psychology
1,072Publications
104H-index
43kCitations
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Publications 1094
Newest
#1Milou Straathof (UU: Utrecht University)H-Index: 2
#2Erwin L. A. Blezer (UU: Utrecht University)H-Index: 27
Last. Maarten Mennes (Radboud University Nijmegen)H-Index: 35
view all 65 authors...
Abstract Obsessive-compulsive disorder (OCD) is increasingly considered to be a neurodevelopmental disorder. However, despite insights in neural substrates of OCD in adults, less is known about mechanisms underlying compulsivity during brain development in children and adolescents. Therefore, we developed an adolescent rat model of compulsive checking behavior and investigated developmental changes in structural and functional measures in the frontostriatal circuitry. Five-weeks old Sprague Dawl...
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#1Thaira J.C. Openneer (UMCG: University Medical Center Groningen)H-Index: 5
#2Natalie J. Forde (Radboud University Nijmegen)H-Index: 5
Last. Andrea Dietrich (UMCG: University Medical Center Groningen)H-Index: 15
view all 7 authors...
Abstract Findings of executive functioning deficits in Tourette syndrome (TS) have so far been inconsistent, possibly due to methodological challenges of previous studies, such as the use of small sample sizes and not accounting for comorbid attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or medication use. We aimed to address these issues by examining several areas of executive functioning (response inhibition, attentional flexibility, cognitive control, an...
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Antipsychotics are often prescribed to children and adolescents, mostly off-label. We aimed to assess adherence to recommendations of guidelines for antipsychotic prescription. We reviewed 436 medical records from 155 clinicians from 26 clinics within three Dutch child and adolescent psychiatry organizations (n = 398 outpatient, n = 38 inpatient care). We assessed target symptoms, diagnostic process, prior and concomitant treatment, and consideration of contra-indications. Multiple logistic regr...
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#1Tobias Kaufmann (Oslo University Hospital)H-Index: 23
#2Karolinska Schizophrenia (UM: Maastricht University)H-Index: 2
Last. Lars T. Westlye (University of Oslo)H-Index: 53
view all 85 authors...
In the version of this article initially published, spaces were missing in the names of Stephanie Le Hellard and Pasquale Di Carlo. The errors have been corrected in the HTML and PDF versions of the article.
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#1Mandy Meijer (Radboud University Nijmegen)
Last. Jonathan MillH-Index: 60
view all 11 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists into adulthood. ADHD and related personality traits, such as impulsivity and callousness, are caused by genetic and environmental factors and their interplay. Epigenetic modifications of DNA, including methylation, are thought to mediate between such factors and behavior and may behave as biomarkers for disorders. Here, we set out to study DNA methylation in persistent ADHD and related traits. We...
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#1Thaira J.C. Openneer (UMCG: University Medical Center Groningen)H-Index: 5
#2Jan-Bernard C. Marsman (UMCG: University Medical Center Groningen)H-Index: 10
Last. Pieter J. Hoekstra (UMCG: University Medical Center Groningen)H-Index: 40
view all 9 authors...
Abstract Little is known about the brain’s functional organization during resting-state in children with Tourette syndrome (TS). We aimed to investigate this with a specific focus on the role of comorbid attention-deficit/hyperactivity disorder (ADHD). We applied graph theoretical analysis to resting-state functional magnetic resonance imaging data of 109 8-to-12-year-old children with TS (n=46), ADHD without tics (n=23), and healthy controls (n=40). First, we compared these three groups, and in...
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#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Sarita A. Dam (Radboud University Nijmegen)
Last. Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
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Abstract Learning from feedback is one of the key mechanisms within cognitive flexibility, which is needed to react swiftly to constantly changing environments. The motivation to change behavior is highly dependent on the expectancy of positive (reward) or negative (punishment) feedback. Individuals with conduct disorder (CD) with high callous unemotional traits show decreased sensitivity to negative feedback and increased reward seeking. Previous studies have modelled traits associated with CD ...
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#1I. Hyun Ruisch (UMCG: University Medical Center Groningen)H-Index: 2
#2Andrea Dietrich (UMCG: University Medical Center Groningen)H-Index: 15
Last. Pieter J. Hoekstra (UMCG: University Medical Center Groningen)H-Index: 40
view all 7 authors...
Aggression and callous, uncaring, and unemotional (CU) traits are clinically related behavioral constructs caused by genetic and environmental factors. We performed polygenic risk score (PRS) analyses to investigate shared genetic etiology between aggression and these three CU-traits. Furthermore, we studied interactions of PRS with smoking during pregnancy and childhood life events in relation to CU-traits. Summary statistics for the base phenotype were derived from the EAGLE-consortium genome-...
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#1Anne-Flore M. Matthijssen (UMCG: University Medical Center Groningen)
#2Andrea Dietrich (UMCG: University Medical Center Groningen)H-Index: 15
Last. Pieter J. Hoekstra (UMCG: University Medical Center Groningen)H-Index: 40
view all 8 authors...
Objectives: To study the effects of discontinuation of long-term methylphenidate use on secondary outcome measures of strengths and difficulties, quality of life (QoL), and parenting stress. Method...
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