Match!
Stephanie K. Dougan
Harvard University
90Publications
25H-index
2,285Citations
Publications 90
Newest
#1Stephanie K. Dougan (Harvard University)H-Index: 25
#2Michael Dougan (Harvard University)H-Index: 15
IL-17 produced by TH17 cells plays a central role in numerous protective and pathologic immune responses. In this issue of Science Signaling, Rizk et al. define a molecular switch controlled by the cellular inhibitor of apoptosis proteins that regulates TH17 immunity.
#1Anjali V. Sheahan (Harvard University)H-Index: 3
#2Katherine L. Morel (Harvard University)H-Index: 4
Last.Phillip Galbo (Albert Einstein College of Medicine)
view all 0 authors...
Prostate cancers are considered immunologically cold tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon (IFN) response genes predicts a favorable response to CPI across various disease sites. The enhancer of zeste homolog-2 (EZH2) is over-expressed in prostate cancer and is known to negatively regulate IFN response genes. Here, we demonstrate that inhibition of EZH2 catalytic activity in prostate cancer models derepresses expr...
#1Eleanor Clancy-Thompson (Harvard University)H-Index: 4
#2Gui Zhen Chen (Harvard University)H-Index: 2
Last.Stephanie K. Dougan (Harvard University)H-Index: 25
view all 10 authors...
#1Michael Dougan (Harvard University)H-Index: 15
#2Stephanie K. Dougan (Harvard University)H-Index: 25
Quorum-sensing bacteria can deliver a nanobody targeting the ‘don’t eat me’ ligand CD47 to tumors that results in systemic anti-tumor immunity-induced regression in mice.
#1Vinod P. Balachandran (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 11
#2Gregory L. Beatty (UPenn: University of Pennsylvania)H-Index: 25
Last.Stephanie K. Dougan (Harvard University)H-Index: 25
view all 3 authors...
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer in the United States by 2025, with 5-year survival at less than 10%. In other recalcitrant cancers, immunotherapy has shown unprecedented response rates, including durable remissions after drug discontinuation. However, responses to immunotherapy in PDAC are rare. Accumulating evidence in mice and humans suggests that this remarkable resistance is linked to the complex, dueling role of the immune system in...
#1Michael Dougan (Harvard University)H-Index: 15
#2Glenn Dranoff (Novartis)H-Index: 14
Last.Stephanie K. Dougan (Harvard University)H-Index: 25
view all 3 authors...
The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also par...
#1Michael Dougan (Harvard University)H-Index: 15
#2Glenn Dranoff (Novartis)H-Index: 14
Last.Stephanie K. Dougan (Harvard University)H-Index: 25
view all 3 authors...
Blocking antibodies to the immune checkpoint receptors or their ligands have revolutionized the treatment of diverse malignancies. Many tumors are recognized by adaptive immunity, but these adaptiv...
#1Eleanor Clancy-Thompson (Harvard University)H-Index: 4
#2C.A. Devlin (MIT: Massachusetts Institute of Technology)
Last.Stephanie K. Dougan (Harvard University)H-Index: 25
view all 10 authors...
T-cell priming occurs when a naive T cell recognizes cognate peptide–MHC complexes on an activated antigen-presenting cell. The circumstances of this initial priming have ramifications on the fate of the newly primed T cell. Newly primed CD8 + T cells can embark onto different trajectories, with some becoming short-lived effector cells and others adopting a tissue resident or memory cell fate. To determine whether T-cell priming influences the quality of the effector T-cell response to tumors, w...
123456789