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Stephanie K. Dougan
Harvard University
87Publications
25H-index
2,281Citations
Publications 87
Newest
Published on May 1, 2019in Gastroenterology 20.77
Vinod P. Balachandran11
Estimated H-index: 11
(Memorial Sloan Kettering Cancer Center),
Gregory L. Beatty25
Estimated H-index: 25
(University of Pennsylvania),
Stephanie K. Dougan25
Estimated H-index: 25
(Harvard University)
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer in the United States by 2025, with 5-year survival at less than 10%. In other recalcitrant cancers, immunotherapy has shown unprecedented response rates, including durable remissions after drug discontinuation. However, responses to immunotherapy in PDAC are rare. Accumulating evidence in mice and humans suggests that this remarkable resistance is linked to the complex, dueling role of the immune system in...
1 Citations Source Cite
Published on Apr 1, 2019in Immunity 19.73
Michael Dougan14
Estimated H-index: 14
(Harvard University),
Glenn Dranoff14
Estimated H-index: 14
(Novartis),
Stephanie K. Dougan25
Estimated H-index: 25
(Harvard University)
The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also par...
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Published on Mar 4, 2019
Michael Dougan14
Estimated H-index: 14
(Harvard University),
Glenn Dranoff14
Estimated H-index: 14
(Novartis),
Stephanie K. Dougan25
Estimated H-index: 25
(Harvard University)
Blocking antibodies to the immune checkpoint receptors or their ligands have revolutionized the treatment of diverse malignancies. Many tumors are recognized by adaptive immunity, but these adaptiv...
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Published on Nov 7, 2018in Cancer immunology research 9.19
Eleanor Clancy-Thompson4
Estimated H-index: 4
(Harvard University),
C.A. Devlin (Massachusetts Institute of Technology)+ 7 AuthorsStephanie K. Dougan25
Estimated H-index: 25
(Harvard University)
T-cell priming occurs when a naive T cell recognizes cognate peptide–MHC complexes on an activated antigen-presenting cell. The circumstances of this initial priming have ramifications on the fate of the newly primed T cell. Newly primed CD8 + T cells can embark onto different trajectories, with some becoming short-lived effector cells and others adopting a tissue resident or memory cell fate. To determine whether T-cell priming influences the quality of the effector T-cell response to tumors, w...
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Published on Oct 1, 2018in Journal of Experimental Medicine 10.79
Yoshinaga Ito10
Estimated H-index: 10
,
Orr Ashenberg10
Estimated H-index: 10
+ 10 AuthorsLuc Teyton62
Estimated H-index: 62
2 Citations Source Cite
Published on Sep 14, 2018in The EMBO Journal 10.56
Ying‐Cing Lin1
Estimated H-index: 1
(Ragon Institute of MGH, MIT and Harvard),
Simone Pecetta6
Estimated H-index: 6
(Ragon Institute of MGH, MIT and Harvard)
+ 9 AuthorsUsha Nair23
Estimated H-index: 23
(Ragon Institute of MGH, MIT and Harvard)
Abstract Here, we describe a one‐step, in vivo CRISPR/Cas9 nuclease‐mediated strategy to generate knock‐in mice. We produced knock‐in (KI) mice wherein a 1.9‐kb DNA fragment bearing a pre‐arranged human B‐cell receptor heavy chain was recombined into the native murine immunoglobulin locus. Our methodology relies on Cas9 nuclease‐induced double‐stranded breaks directed by two sgRNAs to occur within the specific target locus of fertilized oocytes. These double‐stranded breaks are subsequently repa...
2 Citations Source Cite
Published on Sep 7, 2018in Frontiers in Immunology 5.51
Sayeda Yasmin-Karim7
Estimated H-index: 7
(Harvard University),
Patrick Bruck3
Estimated H-index: 3
(Harvard University)
+ 6 AuthorsWilfred Ngwa17
Estimated H-index: 17
(University of Massachusetts Amherst)
Radiation therapy induces immunogenic cell death, which can theoretically stimulate T cell priming and induction of tumor-specific memory T cell responses, serving as an in situ vaccine. In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a single dose of stereotactic body radiation therapy (SBRT) synergizes with intratumoral injection of agonistic anti-CD40, resulting in regression of non-treated contralateral tumors and formation of l...
3 Citations Source Cite
Published on Jul 1, 2018in Immunotherapy 3.46
Stephanie K. Dougan25
Estimated H-index: 25
(Harvard University),
Michael Dougan14
Estimated H-index: 14
(Harvard University)
Inhibition of the T-cell co-inhibitory checkpoint receptors or their ligands CTLA-4, PD-1 and PD-L1 using monoclonal antibodies has proven to be highly effective against many cancers. Yet many cancers remain resistant to checkpoint blockade, and durable remissions occur in only a minority of patients. Novel approaches to enhancing antitumor responses are thus necessary in order to expand the reach of these treatments. The inhibitor of apoptosis (IAP) protein family comprises a diverse group of p...
6 Citations Source Cite
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